Takenaga M, Hirai A, Terano T, Tamura Y, Kitagawa H, Yoshida S
J Pharmacobiodyn. 1987 May;10(5):201-8. doi: 10.1248/bpb1978.10.201.
The in vitro effect of cinnamic aldehyde, a main component of Cinnamomi Cortex, on platelet aggregation and arachidonic acid (AA) metabolism in human platelets was studied. Cinnamic aldehyde reduced platelet aggregation of both platelet rich plasma and washed platelets, dose-dependently. This compound also decreased the formation of the metabolites of AA such as thromboxane B2 (TXB2), 12-hydroxy heptadecatrienoic acid and 12-hydroxyeicosatetraenoic acid in collagen-stimulated washed platelets. The conversion of exogenous [14C]AA to cyclooxygenase metabolites or 12-lipoxygenase metabolite was not altered significantly by the addition of cinnamic aldehyde. On the other hand, collagen-induced release of [14C]AA and its metabolites from washed platelets prelabeled with [14C]AA was markedly reduced by the addition of cinnamic aldehyde. These results suggested that cinnamic aldehyde suppressed the release of AA from platelet membrane phospholipids and then reduced the formation of thromboxane A2. This inhibitory effect of cinnamic aldehyde on AA release and TXB2 formation may contribute to reduced platelet aggregation.
研究了肉桂皮主要成分肉桂醛对人血小板聚集及花生四烯酸（AA）代谢的体外作用。肉桂醛可剂量依赖性地降低富血小板血浆和洗涤血小板的血小板聚集。该化合物还可减少胶原刺激的洗涤血小板中AA代谢产物如血栓素B2（TXB2）、12-羟基十七碳三烯酸和12-羟基二十碳四烯酸的形成。添加肉桂醛对外源性[14C]AA向环氧化酶代谢产物或12-脂氧合酶代谢产物的转化无明显改变。另一方面，添加肉桂醛可显著减少胶原诱导的[14C]AA及其代谢产物从预先用[14C]AA标记的洗涤血小板中的释放。这些结果表明，肉桂醛抑制了AA从血小板膜磷脂中的释放，进而减少了血栓素A2的形成。肉桂醛对AA释放和TXB2形成的这种抑制作用可能有助于减少血小板聚集。
