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一种阿育吠陀配方Chaturmukha Rasa的抗糖尿病活性：一项基于机制的研究。

Antidiabetic Activity of an Ayurvedic Formulation Chaturmukha Rasa: A Mechanism Based Study.

作者信息

Sharma Akansha, Tiwari Raj K, Sharma Vikas, Pandey Ravindra K, Shukla Shiv Shnakar

机构信息

Research scholar, Columbia Institute of Pharmacy, Raipur, C.G., India.

Department of Pharmacology, Columbia Institute of Pharmacy, Raipur, C.G., India.

出版信息

J Pharmacopuncture. 2019 Jun;22(2):115-121. doi: 10.3831/KPI.2019.22.015. Epub 2019 Jun 30.

DOI:10.3831/KPI.2019.22.015
PMID:31338252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6645346/
Abstract

OBJECTIVES

The objective of this study was to evaluate antidiabetic activity of based on streptozotocin induced diabetes model, alpha amylase inhibitory activity, alpha Glucosidase inhibitory activity and inhibition of sucrase.

METHODS

was prepared as per Ayurvedic formulary. Antidiabetic activity was measured in experimentally streptozotocin induced rats. The dose was taken as 45 mg/kg, i.p. The antidiabetic activity of was compared Triphala Kwatha, a marketed formulation. Further In vitro ά-Amylase Inhibitory Assay, In vitro salivary amylase Inhibitory Assay, In vitro α-Glucosidase Inhibitory Assay and In vitro Sucrase Inhibitory Assay was performed with respect to . The IC50 value was calculated for all the above activity.

RESULTS

Streptozotocin with Acarbose showed significant decrease in blood glucose level whereas streptozotocin with Triphala kwatha showed more decrease in blood glucose level than Streptozotocin with Acarbose. The combination of Streptozotocin + Triphala kwatha + showed a significant decrease in blood glucose level on 21st day. In vitro ά-Amylase Inhibitory Assay the showed IC50 value 495.94 μl when compared with Acarbose 427.33 μl, respectively. In the α-Glucosidase Inhibitory Assay showed IC50 value 70.93 μl when compared with Acarbose 102.28 μl, respectively. In vitro Sucrase Inhibitory Assay showed IC50 value 415.4 μl when compared with Acarbose 371.43 μl, respectively.

CONCLUSION

This study supports that may inhibit diabetes by inhibition of salivary amylase or alpha Glucosidase or sucrase. This may be the mechanism by which inhibits diabetes. Further this study supports the usage of for the management of diabetes.

摘要

目的

本研究的目的是基于链脲佐菌素诱导的糖尿病模型、α淀粉酶抑制活性、α葡萄糖苷酶抑制活性和蔗糖酶抑制作用来评估[药物名称未给出]的抗糖尿病活性。

方法

[药物名称未给出]按照阿育吠陀配方制备。在实验性链脲佐菌素诱导的大鼠中测量抗糖尿病活性。剂量为45毫克/千克，腹腔注射。将[药物名称未给出]的抗糖尿病活性与市售制剂三果汤进行比较。进一步对[药物名称未给出]进行了体外α淀粉酶抑制试验、体外唾液淀粉酶抑制试验、体外α葡萄糖苷酶抑制试验和体外蔗糖酶抑制试验。计算了上述所有活性的IC50值。

结果

链脲佐菌素与阿卡波糖联合使用可使血糖水平显著降低，而链脲佐菌素与三果汤联合使用比链脲佐菌素与阿卡波糖联合使用使血糖水平降低得更多。链脲佐菌素+三果汤+[药物名称未给出]的组合在第21天使血糖水平显著降低。在体外α淀粉酶抑制试验中，[药物名称未给出]的IC50值为495.94微升，而阿卡波糖为427.33微升。在α葡萄糖苷酶抑制试验中，[药物名称未给出]的IC50值为70.93微升，而阿卡波糖为102.28微升。在体外蔗糖酶抑制试验中，[药物名称未给出]的IC50值为415.4微升，而阿卡波糖为371.43微升。

结论

本研究支持[药物名称未给出]可能通过抑制唾液淀粉酶或α葡萄糖苷酶或蔗糖酶来抑制糖尿病。这可能是[药物名称未给出]抑制糖尿病的机制。此外，本研究支持[药物名称未给出]用于糖尿病管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/7d52870cbbe6/2093-6966-v22-n02-115f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/7c310f94d440/2093-6966-v22-n02-115f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/35f8578df53a/2093-6966-v22-n02-115f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/fb7e49a5eb6e/2093-6966-v22-n02-115f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/7d52870cbbe6/2093-6966-v22-n02-115f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/7c310f94d440/2093-6966-v22-n02-115f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/35f8578df53a/2093-6966-v22-n02-115f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/fb7e49a5eb6e/2093-6966-v22-n02-115f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27d5/6645346/7d52870cbbe6/2093-6966-v22-n02-115f4.jpg

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