Research and Development Centre, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India.
Department of Biotechnology, Faculty of Biomedical Sciences, Uttarakhand Ayurved University, Dehradun, India.
Nat Prod Res. 2022 Mar;36(5):1300-1305. doi: 10.1080/14786419.2020.1858414. Epub 2020 Dec 17.
is used for the management of diabetes mellitus in the Indian subcontinent. The present work aimed to validate the traditional claim of the plant in diabetes mellitus. studies were conducted using α-glucosidase and α-amylase assays whereas streptozotocin-nicotinamide-induced diabetic Wistar rats were used for study. The aqueous-ethanol extract from the aerial parts was found to exhibit α-glucosidase and α-amylase inhibitory activities with the IC values of 31.0 and 17.2 mg/mL, respectively when compared with acarbose (IC = 8.6 and 16.25 mg/mL, respectively). The extract showed a significant glucose-lowering effect in diabetic rats at the doses of 200 and 400 mg/kg in a dose-dependent manner, while acarbose (10 mg/kg) was used as a standard. The results revealed that aerial parts showed antidiabetic activity via inhibiting α-glucosidase and α-amylase enzymes. The present study also validated the ethnomedicinal claim of the plant in diabetes mellitus.
在印度次大陆，用于治疗糖尿病。本研究旨在验证该植物在糖尿病方面的传统功效。研究采用α-葡萄糖苷酶和α-淀粉酶测定法进行，同时还使用链脲佐菌素-烟酰胺诱导的糖尿病 Wistar 大鼠进行研究。结果表明，与阿卡波糖（IC = 8.6 和 16.25 mg/mL）相比，来自地上部分的水-乙醇提取物对α-葡萄糖苷酶和α-淀粉酶具有抑制活性，IC 值分别为 31.0 和 17.2 mg/mL。该提取物在 200 和 400 mg/kg 剂量下，以剂量依赖性方式显示出对糖尿病大鼠的显著降血糖作用，而阿卡波糖（10 mg/kg）用作标准。结果表明，地上部分通过抑制α-葡萄糖苷酶和α-淀粉酶来发挥抗糖尿病作用。本研究还验证了该植物在糖尿病中的传统医学用途。
