Cimo P L, Pisciotta A V, Desai R G, Pino J L, Aster R H
Am J Hematol. 1977;2(1):65-72. doi: 10.1002/ajh.2830020109.
Sudden, severe thrombocytopenia developed in each of three patients receiving diphenylhydantion, diazepam, and sulfisoxazole, respectively. Recovery followed discontinuance of the drugs. An antiplatelet antibody requiring the presence of an appropriate drug for interaction with platelets was deomonstrated in each case by the 51Cr platelet lysis test using normal, paroxysmal nocturnal hemoglobinuric, or enzyme-treated normal platelets as target cells. These antibodies could not be detected by techniques that depend on clot retraction inhibition, complement fixation, or platelet factor-3 activation. Quinine-and quinidine-dependent antiplatelet antibodies in the serum of 16 patients who developed acute thrombocytopenia while taking either quinine or quinidine could be demonstrated readily with the 51Cr platelet lysis test and could also be detected by other methods employed.
分别接受苯妥英、地西泮和磺胺异恶唑治疗的三名患者均突然出现严重血小板减少。停药后血小板数量恢复。通过使用正常、阵发性夜间血红蛋白尿或酶处理的正常血小板作为靶细胞的51Cr血小板溶解试验，在每种情况下均证明存在一种需要适当药物才能与血小板相互作用的抗血小板抗体。这些抗体不能通过依赖于凝块回缩抑制、补体固定或血小板因子3激活的技术检测到。对于16名在服用奎宁或奎尼丁时发生急性血小板减少的患者血清中奎宁和奎尼丁依赖性抗血小板抗体，用51Cr血小板溶解试验很容易证明，也可以通过其他采用的方法检测到。
