Kaartinen Sara, Aaltonen Sari, Korhonen Tellervo, Latvala Antti, Mikkelsson Marja, Kujala Urho M, Kaprio Jaakko
Department of Public Health, P.O. Box 20 (Tukholmankatu 8 B), FI-00014, University of Helsinki, Helsinki, Finland.
Department of Social Research, P.O. Box 54, University of Helsinki, FI-00014 Helsinki, Finland.
Prev Med Rep. 2019 Jul 4;15:100933. doi: 10.1016/j.pmedr.2019.100933. eCollection 2019 Sep.
This study investigates cross-sectional and longitudinal associations between the diversity of leisure-time sport activities and the frequencies of low back pain (LBP) and neck-shoulder region pain (NSP) in twins, including a cross-sectional within-pair design to adjust for potential familial confounding. Finnish twins born in 1975-79 (FinnTwin16 study) reported participation in leisure-time sport activities at the mean ages of 17 (1992-96) ( = 5096, 54% females) and 34 years (2010-12) ( = 3731, 57% females). Diversity assessed as the number of sport activities was categorized as 1, 2, 3, 4, and ≥ 5, excluding inactive individuals. The frequencies of LBP ( = 3201) and NSP ( = 3207), reported at age 34, were categorized as never/seldom, monthly, or weekly pain. Cross-sectional and longitudinal individual-based associations between the number of sport activities and the frequency of LBP and NSP were investigated with multinomial logistic regression analyses, adjusting for multiple confounders. Cross-sectionally, participation in ≥5 sport activities, compared to 1 sport, was associated with significantly less weekly LBP (OR = 0.63, 95%CI = 0.43-0.90), but not with NSP. Longitudinally, participation in several sport activities in adolescence had no significant association with LBP or NSP in adulthood. Cross-sectional within-pair analyses were conducted among twin pairs discordant for LBP ( = 507) and NSP ( = 579). The associations between monozygotic and dizygotic twin pairs were similar in LBP-discordant pairs but differed within NSP-discordant pairs. Participation in ≥5 sport activities in adulthood may be associated with less weekly LBP, but not with monthly LBP or the frequency of NSP. However, within-pair analyses for NSP suggest confounding due to shared familial factors.
本研究调查了双胞胎休闲体育活动多样性与腰痛（LBP）和颈肩区域疼痛（NSP）频率之间的横断面和纵向关联，包括采用配对内横断面设计以调整潜在的家族混杂因素。1975 - 1979年出生的芬兰双胞胎（FinnTwin16研究）报告了他们在平均年龄17岁（1992 - 1996年）（n = 5096，54%为女性）和34岁（2010 - 2012年）（n = 3731，57%为女性）时参与休闲体育活动的情况。以体育活动数量评估的多样性分为1、2、3、4和≥5类，不包括不活动的个体。在34岁时报告的LBP（n = 3201）和NSP（n = 3207）频率分为从不/很少、每月或每周疼痛。采用多项逻辑回归分析研究了体育活动数量与LBP和NSP频率之间的基于个体的横断面和纵向关联，并对多个混杂因素进行了调整。横断面分析显示，与参与1项体育活动相比，参与≥5项体育活动与每周LBP显著减少相关（OR = 0.63，95%CI = 0.43 - 0.90），但与NSP无关。纵向分析表明，青少年时期参与多项体育活动与成年期的LBP或NSP无显著关联。在LBP（n = 507）和NSP（n = 579）不一致的双胞胎对中进行了配对内横断面分析。在LBP不一致的双胞胎对中，同卵双胞胎和异卵双胞胎对之间的关联相似，但在NSP不一致的双胞胎对中有所不同。成年期参与≥5项体育活动可能与每周LBP减少有关，但与每月LBP或NSP频率无关。然而，NSP的配对内分析表明存在家族共享因素导致的混杂。
