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自我报告的爬楼梯与全因死亡率和心血管死亡率的关联:哈佛校友健康研究。

Associations of self-reported stair climbing with all-cause and cardiovascular mortality: The Harvard Alumni Health Study.

作者信息

Rey-Lopez Juan Pablo, Stamatakis Emmanuel, Mackey Martin, Sesso Howard D, Lee I-Min

机构信息

The University of Sydney, Charles Perkins Centre, Prevention Research Collaboration, Sydney School of Public Health, Camperdown, New South Wales, Australia.

The University of Sydney, Epidemiology Unit, Camperdown, New South Wales, Australia.

出版信息

Prev Med Rep. 2019 Jun 28;15:100938. doi: 10.1016/j.pmedr.2019.100938. eCollection 2019 Sep.

Abstract

To evaluate the association between numbers of floors climbed (per week) and all-cause and cardiovascular (CVD) mortality in men. A prospective study was conducted in 8874 men (Median [interquartile range] age: 65 years [60-71.6 years]) from the Harvard Alumni Health Study. Participants reported the number of floors habitually climbed, physical activity in their leisure time, other health related behaviours and any physician diagnosed disease in 1988. Men were followed for mortality through December 2008. Multivariate Cox hazard models to examine the association between weekly number of floors climbed and all-cause and CVD mortality adjusted for participation in total physical activity and other confounders. During a median follow-up of 12.4 years, 4063 men died (1195 from CVD). After adjusting for confounders (age, walking, sports/recreation, body mass index, alcohol intake, and smoking, diagnoses of hypertension or diabetes or high cholesterol) number of stairs habitually climbed was inversely associated with all-cause mortality (p trend <0.001). Compared with the group who climbed <10 floors/week, the hazard ratio (HR) for the ≥35 floors/week group was 0.84 95% confidence interval (CI) (0.78-0.91). In contrast, we found no evidence for an association between stair climbing and CVD mortality risk (p trend = 0.38), in the ≥35 floors/week group: HR = 0.94 95%CI (0.81-1.09). In this cohort of older men, stair climbing was associated with a lower risk of mortality from any causes. Further insights may be gained from future observational studies utilizing emerging pattern recognition of stair climbing from objective measurements of physical activity.

摘要

评估男性每周爬楼层数与全因死亡率和心血管疾病(CVD)死亡率之间的关联。对来自哈佛校友健康研究的8874名男性(年龄中位数[四分位间距]:65岁[60 - 71.6岁])进行了一项前瞻性研究。参与者报告了1988年习惯性爬楼的层数、休闲时间的身体活动、其他与健康相关的行为以及任何经医生诊断的疾病。对男性进行随访直至2008年12月以获取死亡率数据。采用多变量Cox风险模型来检验每周爬楼层数与全因死亡率和CVD死亡率之间的关联,并对总体身体活动参与情况及其他混杂因素进行了校正。在中位随访期12.4年期间,4063名男性死亡(1195例死于心血管疾病)。在对混杂因素(年龄、步行、运动/娱乐、体重指数、酒精摄入量、吸烟、高血压或糖尿病或高胆固醇诊断)进行校正后,习惯性爬楼梯的层数与全因死亡率呈负相关(p趋势<0.001)。与每周爬楼<10层的组相比,每周爬楼≥35层组的风险比(HR)为0.84,95%置信区间(CI)为(0.78 - 0.91)。相比之下,我们没有发现爬楼梯与CVD死亡风险之间存在关联的证据(p趋势 = 0.38),在每周爬楼≥35层组中:HR = 0.94,95%CI为(0.81 - 1.09)。在这个老年男性队列中,爬楼梯与较低的全因死亡风险相关。利用从身体活动客观测量中获得的爬楼梯新的模式识别进行未来的观察性研究,可能会获得进一步的见解。

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