Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Department of internal Medicine, Korea University College of Medicine, Seoul, Korea.
Diabetes Metab J. 2019 Dec;43(6):879-892. doi: 10.4093/dmj.2018.0202. Epub 2019 Jun 25.
A premeal load of protein can increase satiety and reduce energy intake. Dietary fiber also conveys metabolic benefits by modulating energy intake. We made a protein-enriched, dietary fiber-fortified bar (PFB) and aimed to investigate its effects on food intake and gut hormone secretion in healthy individuals.
Twenty subjects with normal glucose tolerance were enrolled. On three separate visits, the subjects received, in a randomized order, one of the following: a PFB containing 73 kcal with 10.7 g of protein and 12.7 g of dietary fiber; a usual bar (UB) containing the same calories as the PFB but only 0.9 g of protein and no dietary fiber; or water (control). After 15 minutes, the subjects had intake of a test meal. Food consumption, appetite, and plasma gut hormone levels were measured.
Total energy intake, including the bar and the test meal, was significantly reduced with the PFB preload compared to the water (904.4±534.9 kcal vs. 1,075.0±508.0 kcal, =0.016). With the UB preload, only the intake of the test meal was reduced (=0.044) but not the total energy intake (=0.471) than the water. Fullness was also significantly increased after the PFB. In addition, postprandial glucose levels decreased and glucagon-like peptide-1 levels increased with the PFB compared with both the UB and water.
In healthy individuals, a premeal supplementation of PFB reduced total energy intake and decreased postprandial glucose excursion. This finding necessitates long-term studies regarding clinical use in obesity.
餐前摄入蛋白质可以增加饱腹感并减少能量摄入。膳食纤维还可以通过调节能量摄入来带来代谢益处。我们制作了一种富含蛋白质和膳食纤维的强化棒（PFB），并旨在研究其对健康个体的食物摄入和肠道激素分泌的影响。
共有 20 名糖耐量正常的受试者入组。在 3 次单独的访视中，受试者随机接受以下三种处理之一：一种含有 73 千卡热量、10.7 克蛋白质和 12.7 克膳食纤维的 PFB；一种与 PFB 具有相同热量但仅含有 0.9 克蛋白质和不含膳食纤维的普通棒（UB）；或水（对照）。15 分钟后，受试者摄入测试餐。测量食物摄入量、食欲和血浆肠道激素水平。
与水相比，PFB 预负荷可显著减少总能量摄入，包括棒和测试餐（904.4±534.9 千卡 vs. 1,075.0±508.0 千卡，=0.016）。与水相比，UB 预负荷仅减少了测试餐的摄入量（=0.044），但未减少总能量摄入（=0.471）。食用 PFB 后饱腹感也明显增加。此外，与 UB 和水相比，PFB 可降低餐后血糖水平并增加胰高血糖素样肽-1 水平。
在健康个体中，餐前补充 PFB 可减少总能量摄入并降低餐后血糖波动。这一发现需要在肥胖症的临床应用方面开展长期研究。
