Istituto Italiano di Tecnologia (IIT), Nano Carbon Materials, via Livorno 60, 10144 Turin, Italy.
Trinity College Dublin, School of Chemistry, College Green, Dublin 2, Ireland.
Dalton Trans. 2019 Nov 7;48(41):15537-15544. doi: 10.1039/c9dt02092f. Epub 2019 Jul 24.
The supramolecular assembly of acetylsalicylic acid to a merocyanine-Zn complex translates into a photo-controllable drug delivery system. Herein, we present the synthesis and spectroscopic analysis of a three-component assembly combining a spiropyran derivative, a zinc(ii) cation, and acetylsalicylic acid. The ON/OFF system can be modulated by safe and easily affordable stimuli, for the specific delivery of more than one active compound. Our results confirm the formation of a ternary system in solution, where the behaviour is dominated by photo-induced responses, and pave the way for the use of such smart platforms for medicinal chemistry purposes.
阿司匹林与甲川菁锌配合物的超分子组装转化为光控药物输送系统。在此，我们介绍了一种三组分组装体的合成和光谱分析，该组装体结合了螺吡喃衍生物、锌（II）阳离子和阿司匹林。该 ON/OFF 系统可以通过安全且易于负担的刺激来调节，用于特定输送多种活性化合物。我们的结果证实了三元体系在溶液中的形成，其中行为主要由光诱导响应决定，并为这种智能平台在药物化学中的应用铺平了道路。
