Lima L A, Murphy J F, Stansbie D, Rowlandson P, Gray O P
Department of Child Health, University of Wales College of Medicine, Cardiff, UK.
Acta Paediatr Scand. 1988 May;77(3):332-9. doi: 10.1111/j.1651-2227.1988.tb10657.x.
Fifty-one newborn infants requiring parenteral nutrition were randomly assigned to receive a 50% medium chain triglyceride/50% long chain triglyceride lipid emulsion or the conventional 100% long chain triglyceride emulsion. Fat was administered daily for 20 hours, to a maximum of 3 g/kg/day. Plasma triglycerides, cholesterol, free fatty acids, ketones, glucose and capillary blood gases were monitored daily up to the sixth day of fat infusion. There were no significant differences in mean plasma triglycerides and free fatty acids between the two groups. No cases of hyperketonaemia were detected in the infants studied. Hyperglycaemic episodes were detected with similar frequency in both groups. The group who received the emulsion containing medium chain triglycerides had significantly lower mean plasma cholesterol values during the study. After 6 days of intravenous fat administration mean plasma cholesterol was more than 100% higher in the group which received the conventional emulsion. Differences in cholesterol content between the emulsions and a cholesterol lowering effect of medium chain triglycerides are possible explanations for these findings.
51名需要肠外营养的新生儿被随机分配，分别接受50%中链甘油三酯/50%长链甘油三酯脂肪乳剂或传统的100%长链甘油三酯脂肪乳剂。脂肪每天输注20小时，最大剂量为3g/kg/天。在脂肪输注的第6天前，每天监测血浆甘油三酯、胆固醇、游离脂肪酸、酮体、葡萄糖和毛细血管血气。两组间平均血浆甘油三酯和游离脂肪酸无显著差异。在所研究的婴儿中未检测到高酮血症病例。两组中高血糖发作的频率相似。在研究期间，接受含中链甘油三酯脂肪乳剂的组平均血浆胆固醇值显著较低。静脉输注脂肪6天后，接受传统脂肪乳剂的组平均血浆胆固醇高出100%以上。脂肪乳剂中胆固醇含量的差异以及中链甘油三酯的降胆固醇作用可能是这些结果的解释。
