Cairns P A, Wilson D C, Jenkins J, McMaster D, McClure B G
Royal Maternity Hospital, Belfast.
Arch Dis Child Fetal Neonatal Ed. 1996 Sep;75(2):F113-6. doi: 10.1136/fn.75.2.f113.
To compare the effect of concentration of a mixed lipid emulsion (50:50 medium chain triglyceride/long chain triglyceride) (MCT/LCT) on lipid tolerance in neonates.
A prospective randomised controlled trial of 75 neonates requiring prolonged parenteral nutrition was conducted in the neonatal intensive care units of the Royal Maternity Hospital, Belfast, and the Waveney Hospital, Ballymena. Thirty eight infants received 10% and 37 20% lipid emulsion. Infants were randomly assigned to groups at the start of parenteral nutrition and studied if they required seven or more days of this. Lipid tolerance was assessed by twice weekly measurements of plasma triglyceride and cholesterol concentrations and weekly measurement of non-esterified fatty acids and beta hydroxy butyrate. Anthropometry was carried out weekly.
The mean cholesterol in the 10% group was significantly higher within the first seven days of the study compared with the 20% group (3.5 vs 2.87 mmol/l), and continued to rise over the study period in contrast to the 20% group. A similar pattern was observed with the triglyceride concentrations. There was no significant difference in non-esterified fatty acids, beta hydroxy butyrate, or growth between the two groups.
Sick neonates show better biochemical tolerance to 20% MCT/LCT emulsion than to 10% emulsion.
比较混合脂质乳剂（中链甘油三酯/长链甘油三酯比例为50:50）（MCT/LCT）浓度对新生儿脂质耐受性的影响。
在贝尔法斯特皇家妇产医院和巴利米纳韦弗尼医院的新生儿重症监护病房，对75例需要长期肠外营养的新生儿进行了一项前瞻性随机对照试验。38例婴儿接受10%的脂质乳剂，37例接受20%的脂质乳剂。在肠外营养开始时将婴儿随机分组，若需要肠外营养7天或更长时间则纳入研究。通过每周两次测量血浆甘油三酯和胆固醇浓度以及每周测量非酯化脂肪酸和β-羟基丁酸来评估脂质耐受性。每周进行人体测量。
在研究的前7天内，10%组的平均胆固醇水平显著高于20%组（3.5 vs 2.87 mmol/l），且与20%组相比，在研究期间持续上升。甘油三酯浓度也观察到类似模式。两组之间的非酯化脂肪酸、β-羟基丁酸或生长情况没有显著差异。
患病新生儿对20%的MCT/LCT乳剂的生化耐受性优于10%的乳剂。
