Areny Giselle, González Daniel E, Amoedo Diego, Salvay M Cristina, De Marco Ménica B, Bales Francisca, Barreto Juan, Brescovich Miguel, Vallejo Mario, Villafañe Silvia
Laboratorio de Toxicología. Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad de Buenos Aires.
Servicio de Bajo Riesgo. Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", Ciudad de Buenos Aires.
Arch Argent Pediatr. 2019 Aug 1;117(4):245-251. doi: 10.5546/aap.2019.eng.245.
Due to the heavy industrialization of the Autonomous City of Buenos Aires and Greater Buenos Aires, the population may have become exposed to metals. To assess the level of exposure to chromium and mercury in children, it is critical to have local reference values (RVs). Our objective was to determine pediatric RV s for chromium and mercury in a single urine sample.
Children who were not exposed to the studied contaminants and who attended the Department of Low Risk Conditions and the Daycare Center Office of Hospital de Pediatría S.A.M.I.C. "Prof. Dr. Juan P. Garrahan" were included. Urinary chromium (UCr), urinary mercury (UHg), and urinary creatinine were measured. The p95 and its corresponding 95 % confidence interval (CI) were estimated based on the RV concept proposed by the German Human Biomonitoring Commission.
The study included 160 patients. A total of 144 samples from children aged 1-17 years (median: 7 years) were collected. UCr was measured in 137 samples and UHg, in 129 samples. The median value of chromium was 0.54 µg/g of creatinine (range, undetectable to 3.06), while that of mercury was 0.49 µg/g of creatinine (range, undetectable to 7.57).
The RVs for UCr were up to 1.5 µg/L [1.2-2.8] and up to 2.2 µg/g of creatinine [1.8-3.0], and for UHg, up to 2.5 µg/L [1.8-4.8] and 3.2 µg/g of creatinine [2.5-4.7].
由于布宜诺斯艾利斯自治市和大布宜诺斯艾利斯地区的重工业发展，当地居民可能接触到了金属。为评估儿童的铬和汞暴露水平，获取当地参考值（RVs）至关重要。我们的目标是确定单次尿液样本中儿童铬和汞的参考值。
纳入未接触所研究污染物且在“Prof. Dr. Juan P. Garrahan”儿科医院低风险疾病科和日托中心就诊的儿童。检测尿铬（UCr）、尿汞（UHg）和尿肌酐。根据德国人类生物监测委员会提出的参考值概念估算第95百分位数及其相应的95%置信区间（CI）。
该研究纳入了160例患者。共收集了144例1至17岁儿童（中位数：7岁）的样本。其中137份样本检测了UCr，129份样本检测了UHg。铬的中位数为0.54µg/g肌酐（范围：未检出至3.06），汞的中位数为0.49µg/g肌酐（范围：未检出至7.57）。
UCr的参考值为肌酐水平最高达1.5µg/L [1.2 - 2.8]和2.2µg/g [1.8 - 3.0]，UHg的参考值为肌酐水平最高达2.5µg/L [1.8 - 4.8]和3.2µg/g [2.5 - 4.7]。
