早期口腔癌：预后因素及辅助放疗对生存的影响。
Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival.
机构信息
Department of Surgical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India.
Department of Medical Oncology, Rajiv Gandhi Cancer Institute & Research Centre, New Delhi, India.
出版信息
Head Neck. 2019 Oct;41(10):3577-3583. doi: 10.1002/hed.25882. Epub 2019 Jul 24.
BACKGROUND
Early oral cavity cancer has good prognosis but recurrence in them is still not uncommon. There is no general consensus on the prognostic factors and adjuvant therapy that would have a significant impact on survival.
METHODS
A retrospective analysis of early oral cavity cancer patients during the time period 2009-2017. The data regarding demographics, histopathological features, and recurrence patterns were collected and analyzed.
RESULTS
Depth of invasion (DOI) was the most important prognostic factor among all the factors analyzed. Further analysis showed that addition of adjuvant radiotherapy for patients with DOI >5 mm did not show survival benefits (P = .73). Another subset analysis of patients with DOI >10 mm also did not show any survival advantage with adjuvant therapy P = .24.
CONCLUSION
There is no benefit of adding adjuvant RT in patients with DOI > 5 mm or in patients who were upstaged to T3 based only on DOI.
背景
早期口腔癌预后良好，但仍有不少患者出现复发。目前，对于那些对生存有显著影响的预后因素和辅助治疗方法，尚未达成普遍共识。
方法
对 2009 年至 2017 年期间的早期口腔癌患者进行回顾性分析。收集并分析了有关人口统计学、组织病理学特征和复发模式的数据。
结果
在所有分析的因素中，浸润深度（DOI）是最重要的预后因素。进一步分析显示，对于 DOI>5mm 的患者，加用辅助放疗并不能带来生存获益（P=0.73）。对于 DOI>10mm 的亚组分析也显示，辅助治疗并不能带来生存优势（P=0.24）。
结论
对于 DOI>5mm 的患者或仅因 DOI 而升级为 T3 的患者，加用辅助放疗没有获益。
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