Bhaumik Atanu, Peterson Gregory I, Kang Cheol, Choi Tae-Lim
Department of Chemistry , Seoul National University , Seoul 08826 , Republic of Korea.
J Am Chem Soc. 2019 Aug 7;141(31):12207-12211. doi: 10.1021/jacs.9b05822. Epub 2019 Jul 24.
Monomers derived from glucose and galactose, which contain an endocyclic alkene (in the sugar ring) and a terminal alkyne, underwent a cascade polymerization to prepare new polymers with the ring-opened sugar incorporated into the polymer backbone. Polymerizations were well-controlled, as demonstrated by a linear increase in molecular weight with monomer-to-initiator ratio and generally narrow molecular weight dispersity values. The living nature of the polymerization was supported by the preparation of a block copolymer from two different sugar-based monomers. The resulting polymers were also fully degradable. They underwent fast and complete depolymerization to small molecules under acidic conditions.
由葡萄糖和半乳糖衍生而来的单体，含有一个环内烯烃（在糖环中）和一个末端炔烃，进行了串联聚合反应，以制备新的聚合物，其中开环糖被并入聚合物主链。聚合反应得到了很好的控制，分子量随单体与引发剂比例呈线性增加，且分子量分散度值通常较窄，证明了这一点。由两种不同的糖基单体制备嵌段共聚物，支持了聚合反应的活性特征。所得聚合物也完全可降解。在酸性条件下，它们能快速且完全解聚为小分子。
