Health Sciences Institute, Federal University of Mato Grosso, Sinop, Mato Grosso, Brazil.
Entomology Department, Aggeu Magalhães Institute, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil.
Infect Genet Evol. 2019 Nov;75:103974. doi: 10.1016/j.meegid.2019.103974. Epub 2019 Jul 21.
Zika virus (ZIKV) has been intensively studied in South America and across the globe since 2015-2016 epidemics. However, in Brazil - the largest and the most affected country in terms of human infection by this virus, most of the viral molecular information is restricted to metropolitan centers distributed along the Brazilian coast and almost no information is known about the virus spread in most difficult access areas such as the Midwest region of the country. Here, we report two ZIKV complete genomes from samples obtained during arboviral surveillance at the Sinop city, southern border of the Amazonian forest, Midwest Brazil in 2015. Our results show that the virus was introduced in this region through two independent introductions: one occurred at the end of 2014, around the period that the virus was already distributed in other regions of the country and abroad, and a second at the end of 2015. Moreover, these genomes were clustered with other viral strains sampled at distant Brazilian states in line with other findings about the rapid spread of the virus throughout the country.
寨卡病毒（ZIKV）自 2015-2016 年流行以来，在南美洲和全球范围内得到了深入研究。然而，在巴西——这个受该病毒感染人数最多的国家，大多数病毒分子信息仅限于分布在巴西沿海的大都市中心，而关于该病毒在中西部等最难进入地区的传播情况几乎一无所知。在这里，我们报告了 2015 年在巴西中西部亚马逊森林南部边境的辛波市进行虫媒病毒监测时获得的两个寨卡病毒完整基因组。我们的结果表明，该病毒是通过两次独立的传入事件进入该地区的：一次发生在 2014 年底，此时病毒已经在该国其他地区和国外传播，另一次发生在 2015 年底。此外，这些基因组与在巴西其他遥远州采样的其他病毒株聚类，与病毒在全国范围内迅速传播的其他发现一致。
