Department of Gynecologic Oncology, Uludag University Hospital, Bursa, Turkey,
Department of Gynecologic Oncology, İzmir Katip Çelebi University, İzmir, Turkey.
Oncol Res Treat. 2019;42(9):466-469. doi: 10.1159/000501727. Epub 2019 Jul 24.
Although there are several reports on omentum metastasis, limited studies have evaluated omental micrometastases, particularly isolated microscopic metastases in endometrial cancer (EC). We performed this study to assess the frequency of omental micrometastasis in EC, especially when the omentum is the only site of extrauterine spread.
A retrospective study was conducted to assess cases of EC with an omental sample during primary surgical treatment for EC at the Gynecological Oncology Unit, Uludag University Hospital, Bursa, Turkey, between January 2005 and May 2018.
In total, 435 patients fulfilled the inclusion criteria, which comprised a complete surgical staging. The prevalence of omental metastases was 5.3% (n = 23), regardless of the subtype or clinical stage. Omental micrometastasis was detected in four cases (17.4%). In half of these patients, the omentum was the only site of disease outside the uterus, with an estimated 0.46% of isolated omental involvement. The grade of the endometrioid tumor was found to be statistically correlated with omental metastases (p = 0.01). There was a significant correlation between omental metastasis and positive peritoneal cytology, as well as adnexal involvement (p = 0.001 and p = 0.03, respectively).
We recommend omentectomy routinely in serous EC. In addition, we suggest selective omentectomy in patients with EC who have concomitant adnexal involvement or grade 3 tumors.
尽管有许多关于网膜转移的报道，但有限的研究评估了网膜微转移，特别是子宫内膜癌（EC）中的孤立显微镜下转移。我们进行这项研究是为了评估 EC 中网膜微转移的频率，特别是当网膜是宫外扩散的唯一部位时。
回顾性研究评估了土耳其布尔萨乌鲁达大学医院妇科肿瘤科在 2005 年 1 月至 2018 年 5 月期间对原发性 EC 手术治疗期间有网膜样本的 EC 病例。
共有 435 名患者符合纳入标准，包括完整的手术分期。网膜转移的患病率为 5.3%（n = 23），与亚型或临床分期无关。网膜微转移在 4 例（17.4%）中被发现。在这些患者的一半中，网膜是子宫外唯一的疾病部位，估计孤立性网膜受累为 0.46%。子宫内膜样肿瘤的分级与网膜转移呈统计学相关（p = 0.01）。网膜转移与阳性腹膜细胞学和附件受累之间存在显著相关性（p = 0.001 和 p = 0.03）。
我们建议在浆液性 EC 中常规行网膜切除术。此外，我们建议在伴有附件受累或 3 级肿瘤的 EC 患者中选择性行网膜切除术。
