Faculdade de Ciências Medicas de Minas Gerais - Instituto de Pós-Graduação, Belo Horizonte, MG - Brazil.
Arq Bras Cardiol. 2019 Jul 18;113(2):242-249. doi: 10.5935/abc.20190123.
Psoriasis correlates with metabolic disorders, early atheromatosis and increased cardiovascular risk.
To assess markers of cardiovascular disease in psoriatic patients.
Cross-sectional, observational study involving 11 psoriatic participants and 33 controls. Anthropometric, biochemical, hemodynamic and imaging parameters were evaluated. Arterial stiffness was assessed by oscillometric measurement of the brachial artery. Intima-media thickness (IMT) and left ventricular diastolic function were assessed by Doppler echography and echocardiography. Between-group comparisons of numerical variables were performed by the Student's t-test or Wilcoxon Mann-Whitney test for independent samples. Significance level was set at 5%.
Psoriatic patients showed increased pulse wave velocity (PWV) (9.1 ± 1.8 vs 8.0 ± 2 m/s, p = 0.033), IMT of the left common carotid artery (p = 0.018) and a higher percentage of patients above the 75th percentile according to the ELSA table when compared with controls (54.5 vs 18.2%, p = 0.045). Psoriatic patients also showed an increase in peripheral/central systolic blood pressure (137.1 ± 13.2 vs 122.3 ± 11.6 mmHg, p = 0.004)/(127 ± 13 vs 112.5 ± 10.4 mmHg, p = 0.005), peripheral/central diastolic blood pressure (89.9 ± 8.9 vs 82.2 ± 8, p = 0.022)/(91 ± 9.3 vs 82.2 ± 8.3, p = 0.014), total cholesterol (252 ± 43.5 vs 198 ± 39.8 mg/dL, p < 0.001), LDL cholesterol (167 ± 24 vs 118 ± 40.8 mg/dL, p < 0.001) and C-reactive protein (7.6 ± 35.4 vs 1 ± 1.2 mg/L p < 0.001) compared with controls.
Psoriasis patients show increased PWV, IMT, peripheral and central blood pressures, and serum cholesterol and C-reactive protein levels, denoting a higher cardiovascular risk.
银屑病与代谢紊乱、早期动脉粥样硬化和心血管风险增加有关。
评估银屑病患者的心血管疾病标志物。
这是一项涉及 11 名银屑病患者和 33 名对照者的横断面、观察性研究。评估了人体测量学、生化、血液动力学和影像学参数。通过肱动脉振荡测量评估动脉僵硬度。通过多普勒超声心动图和超声心动图评估内-中膜厚度（IMT）和左心室舒张功能。通过学生 t 检验或独立样本 Wilcoxon 曼-惠特尼检验比较两组间数值变量。设定显著性水平为 5%。
与对照组相比，银屑病患者的脉搏波速度（PWV）升高（9.1 ± 1.8 对 8.0 ± 2 m/s，p = 0.033）、左颈总动脉 IMT 增加（p = 0.018）和超过 ELSA 表第 75 百分位数的患者比例更高（54.5%对 18.2%，p = 0.045）。银屑病患者的外周/中心收缩压（137.1 ± 13.2 对 122.3 ± 11.6 mmHg，p = 0.004）/（127 ± 13 对 112.5 ± 10.4 mmHg，p = 0.005）、外周/中心舒张压（89.9 ± 8.9 对 82.2 ± 8，p = 0.022）/（91 ± 9.3 对 82.2 ± 8.3，p = 0.014）、总胆固醇（252 ± 43.5 对 198 ± 39.8 mg/dL，p < 0.001）、LDL 胆固醇（167 ± 24 对 118 ± 40.8 mg/dL，p < 0.001）和 C 反应蛋白（7.6 ± 35.4 对 1 ± 1.2 mg/L，p < 0.001）均高于对照组。
银屑病患者的 PWV、IMT、外周和中心血压以及血清胆固醇和 C 反应蛋白水平升高，提示心血管风险较高。
