Jiménez Constanza, Bordagaray María José, Villarroel José Luis, Flores Tania, Benadof Dafna, Fernández Alejandra, Valenzuela Fernando
Faculty of Dentistry, Universidad Andres Bello, Santiago 8370133, Chile.
Department of Conservative Dentistry, Faculty of Dentistry, Universidad de Chile, Santiago 8380544, Chile.
Life (Basel). 2022 Mar 29;12(4):501. doi: 10.3390/life12040501.
Psoriasis is a prevalent worldwide chronic immuno-inflammatory skin disease with various variants and atypical cases. The use of biomarkers for the diagnosis of psoriasis can favor timely treatment and thus improve the quality of life of those affected. In general, the search for biomarkers in oral fluids is recommended as it is a non-invasive and fast technique. This narrative review aimed to identify biomarkers in gingival crevicular fluid (GCF) and saliva to diagnose psoriasis. To achieve this goal, we selected the available literature using the following MESH terms: "psoriasis", "saliva" and "gingival crevicular fluid". The studies analyzed for this review cover original research articles available in English. We found three full articles available for psoriasis biomarkers in GCF and ten articles available for psoriasis biomarkers in saliva. Studies showed that in the saliva of healthy individuals and those with psoriasis, there were differences in the levels of inflammatory cytokines, immunoglobulin A, and antioxidant biomarkers. In GCF, individuals with psoriasis showed higher levels of S100A8, IL-18 and sE-selectin in comparison to healthy individuals, independent of periodontal status. Despite these findings, more studies are required to determine an adequate panel of biomarkers to use in saliva or GCF for psoriasis.
银屑病是一种在全球范围内普遍存在的慢性免疫炎症性皮肤病，有多种变体和非典型病例。使用生物标志物诊断银屑病有助于及时治疗，从而提高患者的生活质量。一般来说，推荐在口腔液中寻找生物标志物，因为这是一种非侵入性的快速技术。本叙述性综述旨在确定龈沟液（GCF）和唾液中的生物标志物以诊断银屑病。为实现这一目标，我们使用以下医学主题词（MESH）选择了现有文献：“银屑病”、“唾液”和“龈沟液”。本次综述分析的研究涵盖了英文的原始研究文章。我们发现有三篇关于GCF中银屑病生物标志物的完整文章，以及十篇关于唾液中银屑病生物标志物的文章。研究表明，健康个体和银屑病患者的唾液中，炎症细胞因子、免疫球蛋白A和抗氧化生物标志物的水平存在差异。在GCF中，与健康个体相比，银屑病患者的S100A8、IL-18和可溶性E选择素水平更高，且与牙周状况无关。尽管有这些发现，但仍需要更多研究来确定用于银屑病诊断的唾液或GCF中合适的生物标志物组合。
