Weiss Rita V, Hohl Alexandre, Athayde Amanda, Pardini Dolores, Gomes Larissa, Oliveira Monica de, Meirelles Ricardo, Clapauch Ruth, Spritzer Poli Mara
Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Pontifícia Universidade Católica do Rio de Janeiro, Escola Médica de Pós-Graduação em Endocrinologia (IEDE-PUC/RJ), Rio de Janeiro, RJ, Brasil.
Serviço de Endocrinologia e Metabolismo, Departamento de Medicina Interna, Hospital Universitário (HU), Universidade Federal de Santa Catarina (UFSC), Florianópolis, SC, Brasil.
Arch Endocrinol Metab. 2019 Jul 18;63(3):190-198. doi: 10.20945/2359-3997000000152.
To summarize current evidence regarding testosterone treatment for women with low sexual desire.
The Female Endocrinology and Andrology Department of the Brazilian Society of Endocrinology and Metabolism invited nine experts to review the physiology of testosterone secretion and the use, misuse, and side effects of exogenous testosterone therapy in women, based on the available literature and guidelines and statements from international societies.
Low sexual desire is a common complaint in clinical practice, especially in postmenopausal women, and may negatively interfere with quality of life. Testosterone seems to exert a positive effect on sexual desire in women with sexual dysfunction, despite a small magnitude of effect, a lack of long-term safety data, and insufficient evidence to make a broad recommendation for testosterone therapy. Furthermore, there are currently no testosterone formulations approved for women by the relevant regulatory agencies in the United States, Brazil, and most other countries, and testosterone formulations approved for men are not recommended for use by women.
Therefore, testosterone therapy might be considered if other strategies fail, but the risks and benefits must be discussed with the patient before prescription. Arch Endocrinol Metab. 2019;63(3):190-8.
总结目前有关睾酮治疗性欲低下女性的证据。
巴西内分泌与代谢学会女性内分泌与男科学部邀请了九位专家，根据现有文献、指南以及国际学会的声明，对睾酮分泌生理学以及女性外源性睾酮治疗的使用、误用和副作用进行综述。
性欲低下是临床实践中的常见主诉，尤其是在绝经后女性中，可能会对生活质量产生负面影响。睾酮似乎对性功能障碍女性的性欲有积极作用，尽管作用程度较小，缺乏长期安全性数据，且没有足够证据广泛推荐睾酮治疗。此外，目前美国、巴西和大多数其他国家的相关监管机构均未批准用于女性的睾酮制剂，且不建议女性使用已批准用于男性的睾酮制剂。
因此，如果其他策略失败，可以考虑睾酮治疗，但在开处方前必须与患者讨论风险和益处。《内分泌与代谢档案》。2019年；63(3)：190 - 198。
