Syntheses of Benzo[]Thiazol-2(3)-One Derivatives and Their Antidepressant and Anticonvulsant Effects.

Thirty-four new benzo[]thiazol derivatives -, -, and - were synthesized and investigated for their potential antidepressant and anticonvulsant effects. In a forced swimming test, and showed the highest antidepressant and anticonvulsant effects. and displayed a higher percentage decrease in immobility duration (89.96% and 89.62%, respectively) than that of fluoxetine (83.62%). In the maximal electroshock seizure test, and showed the highest anticonvulsant effect, with ED values of 46.1 and 64.3 mg kg, and protective indices of 6.34 and 4.11, respectively, which were similar to those of phenobarbital or valproate. We also found that the mechanism for the antidepressant activity of and may be via increasing the concentrations of serotonin and norepinephrine.