Cao Kai, Xu Jie, Zhao Wei-Qi
Beijing Institute of Ophthalmology, Beijing Tongren Hospital of Capital Medical University, Beijing 100005, China.
Int J Ophthalmol. 2019 Jul 18;12(7):1158-1162. doi: 10.18240/ijo.2019.07.17. eCollection 2019.
To develop an automatic tool on screening diabetic retinopathy (DR) from diabetic patients.
We extracted textures from eye fundus images of each diabetes subject using grey level co-occurrence matrix method and trained a Bayesian model based on these textures. The receiver operating characteristic (ROC) curve was used to estimate the sensitivity and specificity of the Bayesian model.
A total of 1000 eyes fundus images from diabetic patients in which 298 eyes were diagnosed as DR by two ophthalmologists. The Bayesian model was trained using four extracted textures including contrast, entropy, angular second moment and correlation using a training dataset. The Bayesian model achieved a sensitivity of 0.949 and a specificity of 0.928 in the validation dataset. The area under the ROC curve was 0.938, and the 10-fold cross validation method showed that the average accuracy rate is 93.5%.
Textures extracted by grey level co-occurrence can be useful information for DR diagnosis, and a trained Bayesian model based on these textures can be an effective tool for DR screening among diabetic patients.
开发一种从糖尿病患者中筛查糖尿病视网膜病变(DR)的自动工具。
我们使用灰度共生矩阵法从每位糖尿病患者的眼底图像中提取纹理,并基于这些纹理训练了一个贝叶斯模型。使用受试者工作特征(ROC)曲线来估计贝叶斯模型的敏感性和特异性。
总共收集了1000例糖尿病患者的眼底图像,其中298只眼睛被两名眼科医生诊断为患有DR。使用包括对比度、熵、角二阶矩和相关性在内的四种提取纹理,利用训练数据集对贝叶斯模型进行训练。在验证数据集中,贝叶斯模型的敏感性达到0.949,特异性达到0.928。ROC曲线下面积为0.938,10倍交叉验证法显示平均准确率为93.5%。
通过灰度共生矩阵提取的纹理可为DR诊断提供有用信息,基于这些纹理训练的贝叶斯模型可成为糖尿病患者DR筛查的有效工具。