School of Laboratory Science, Tianjin Medical University, Tianjin 300203, China.
The Department of Laboratory Science, Tianjin Anding Hospital, Tianjin 300222, China.
Biomed Res Int. 2019 Jun 25;2019:8107906. doi: 10.1155/2019/8107906. eCollection 2019.
Ovarian cancer cases with low CA125 concentration are problematic and increase the high false negative results ratio during routine physical examination testing. Unfortunately, patients without early discovery have very low survival rates. In our study, we investigated the possible role of differential leukocyte counts and the neutrophil-to-lymphocyte ratio (NLR) in ovarian cancer patients to identify an additional discriminative marker to avoid missing diagnoses in normal physical examinations. One hundred seventy-three patients with epithelial ovarian cancer and 70 healthy controls were involved in our study. Based on the results, compared with the healthy controls, NLR was significantly different both in the low CA125 concentration group and in the complete patient group, indicating that NLR could be an effective marker for ovarian cancer screening. According to ROC, sensitivity, specificity, and NPV results, CA125 >35 U/ml is a good indicator for cancer in routine physical examination. However, in patients with low CA125 concentration, the CA125>7.65 U/ml and NLR >1.72 group yielded increased sensitivity with appropriate specificity and higher NPV results than the CA125 >35 U/ml group. We believe CA125>7.65 U/ml and NLR >1.72 should be effective makers for patients with low CA125 concentration. As a more sensitive and cost-effective strategy, this method could be conducted during routine ovarian cancer screening.
卵巢癌患者中 CA125 浓度较低的情况较为棘手，这会导致常规体检检测的假阴性结果比例升高。不幸的是，未能早期发现的患者生存率非常低。在我们的研究中，我们研究了白细胞分类计数和中性粒细胞与淋巴细胞比值（NLR）在卵巢癌患者中的可能作用，以确定一种额外的鉴别标志物，从而避免在常规体检中漏诊。我们研究了 173 例上皮性卵巢癌患者和 70 名健康对照者。结果表明，与健康对照组相比，低 CA125 浓度组和全部患者组的 NLR 均有显著差异，表明 NLR 可能是卵巢癌筛查的有效标志物。根据 ROC、灵敏度、特异性和 NPV 结果，CA125>35 U/ml 是常规体检中癌症的良好指标。然而，在 CA125 浓度较低的患者中，CA125>7.65 U/ml 和 NLR>1.72 组的灵敏度增加，特异性适当，NPV 结果高于 CA125>35 U/ml 组。我们认为 CA125>7.65 U/ml 和 NLR>1.72 应该是 CA125 浓度较低患者的有效标志物。作为一种更敏感且具有成本效益的策略，这种方法可以在常规卵巢癌筛查中进行。
