Datta Abhirup, Lin Wenyi, Rao Amrita, Diouf Daouda, Kouame Abo, Edwards Jessie K, Bao Le, Louis Thomas A, Baral Stefan
Department of Biostatistics, Johns Hopkins University, Baltimore, MD.
Division of Biostatistics and Bioinformatics, University of California, San Diego, La Jolla, CA.
Stat Public Policy (Phila). 2019;6(1):1-13. doi: 10.1080/2330443X.2018.1546634. Epub 2019 Mar 9.
Côte d'Ivoire has among the most generalized HIV epidemics in West Africa with an estimated half million people living with HIV. Across West Africa, key populations, including gay men and other men who have sex with men (MSM), are often disproportionately burdened with HIV due to specific acquisition and transmission risks. Quantifying population sizes of MSM at the subnational level is critical to ensuring evidence-based decisions regarding the scale and content of HIV prevention interventions. While survey-based direct estimates of MSM numbers are available in a few urban centers across Côte d'Ivoire, no data on MSM population size exists in other areas without any community group infrastructure to facilitate sufficient access to communities of MSM. The data are used in a Bayesian regression setup to produce estimates of the numbers of MSM in areas of Côte d'Ivoire prioritized in the HIV response. Our hierarchical model imputes missing covariates using geo-spatial information and allows for proper uncertainty quantification leading to confidence bounds for predicted MSM population size estimates. This process provided population size estimates where there are no empirical data, to guide the prioritization of further collection of empirical data on MSM and inform evidence-based scaling of HIV prevention and treatment programs for MSM across Côte d'Ivoire.
科特迪瓦是西非艾滋病毒疫情最为普遍的国家之一,估计有50万人感染艾滋病毒。在整个西非,包括男同性恋者和其他男男性行为者(MSM)在内的关键人群,由于特定的感染和传播风险,往往承受着不成比例的艾滋病毒负担。在国家以下层面量化男男性行为者的人口规模,对于确保就艾滋病毒预防干预措施的规模和内容做出基于证据的决策至关重要。虽然科特迪瓦的一些城市中心有基于调查的男男性行为者数量的直接估计数据,但在其他没有任何社区团体基础设施以促进充分接触男男性行为者社区的地区,没有关于男男性行为者人口规模的数据。这些数据用于贝叶斯回归设置,以估计科特迪瓦在艾滋病毒应对中优先考虑的地区的男男性行为者数量。我们的分层模型利用地理空间信息估算缺失的协变量,并允许进行适当的不确定性量化,从而得出预测的男男性行为者人口规模估计值的置信区间。这一过程在没有实证数据的情况下提供了人口规模估计值,以指导进一步收集男男性行为者实证数据的优先排序,并为科特迪瓦各地针对男男性行为者的艾滋病毒预防和治疗项目的基于证据的扩大规模提供信息。