Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University, Shenyang, China.
Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China.
Phytother Res. 2019 Sep;33(9):2448-2456. doi: 10.1002/ptr.6436. Epub 2019 Jul 25.
Peritoneal metastasis is common in advanced gastric cancer patients and is typically associated with a worse prognosis. β-Elemene is a natural compound that can be isolated from the Curcuma wenyujin plant and has been widely used in China to treat a variety of cancers. However, the anti-metastatic impacts of β-elemene on gastric cancer remain unknown. In our study, we found that β-elemene significantly inhibited the migration and invasive capacity of gastric cells in vitro and inhibited the capacity of gastric cancer cells to peritoneally diffuse and metastasize in vivo. Mechanistically, we demonstrated that the anti-metastatic effects of β-elemene were exerted by downregulating the expression of Claudin-1. Furthermore, β-elemene was found to inhibit the metastatic capacity of cells by downregulating FAK phosphorylation, which regulated Claudin-1. Overall, our result revealed that β-elemene inhibited peritoneal metastases from gastric cancer by modulating the FAK/Claudin-1 pathway.
腹膜转移在晚期胃癌患者中很常见，通常与预后较差相关。β-榄香烯是一种从温郁金植物中分离得到的天然化合物，在中国被广泛用于治疗多种癌症。然而，β-榄香烯对胃癌的抗转移作用尚不清楚。在我们的研究中，我们发现β-榄香烯可显著抑制体外胃癌细胞的迁移和侵袭能力，并抑制体内胃癌细胞腹膜扩散和转移的能力。从机制上讲，我们证明β-榄香烯的抗转移作用是通过下调 Claudin-1 的表达来实现的。此外，β-榄香烯通过下调调节 Claudin-1 的 FAK 磷酸化来抑制细胞的转移能力。总的来说，我们的结果表明，β-榄香烯通过调节 FAK/Claudin-1 通路抑制胃癌的腹膜转移。
