Horne R L, Ferguson J M, Pope H G, Hudson J I, Lineberry C G, Ascher J, Cato A
Montevista Center, Las Vegas, NV.
J Clin Psychiatry. 1988 Jul;49(7):262-6.
In a placebo-controlled, double-blind study of the unique antidepressant agent bupropion in the treatment of nondepressed subjects with bulimia (bupropion group, N = 55; placebo group, N = 26), we found the drug significantly superior to placebo in reducing episodes of binge eating and purging. In general, side effects with bupropion were minimal. However, four subjects experienced grand mal seizures during treatment with bupropion, a frequency of seizures far higher than observed in previous studies with this drug. Pending a satisfactory explanation for the occurrence of these seizures, we recommend that bupropion not be administered alone to bulimic patients.
在一项针对独特抗抑郁药安非他酮治疗非抑郁性贪食症患者的安慰剂对照双盲研究中（安非他酮组，N = 55；安慰剂组，N = 26），我们发现该药在减少暴饮暴食和清除行为发作方面显著优于安慰剂。总体而言，安非他酮的副作用极小。然而，有4名受试者在使用安非他酮治疗期间发生了癫痫大发作，其发作频率远高于此前该药物研究中的观察结果。在对这些癫痫发作的发生给出令人满意的解释之前，我们建议不要单独给贪食症患者使用安非他酮。
