1 Oncology Department, Hanoi Medical University, Hanoi, Vietnam.
2 Department of Medical Oncology, National Cancer Hospital, Hanoi, Vietnam.
Cancer Control. 2019 Jan-Dec;26(1):1073274819865279. doi: 10.1177/1073274819865279.
Little is known about breast cancer in Vietnamese women. Previous studies have reported the frequencies of prognostic factors of breast cancer in this population. The aim of this study was to examine the prognostic factors associated with the survival rates of patients with breast cancer treated at the National Cancer Hospital, Hanoi, Vietnam. We recruited 248 women with operable breast cancer treated with surgery and adjuvant therapy. Tumor tissue samples were stained by many immunohistochemical approaches and analyzed for estrogen receptor, progesterone receptor, and gene amplification status. A Cox model was used to determine the relationship between survival and the prognostic factors. The disease-free survival rate, overall survival rate, and cancer-specific survival rate were 75.8%, 80.6%, and 86.4%, respectively, at 5 years and 62.3%, 68.1%, and 78.9%, respectively, at 10 years. The lung was the most common metastatic site. Women with factors associated with a poor prognosis (eg, advanced clinical stage, high tumor grade, progesterone receptor [PR] negativity, amplification) had significantly lower survival rates. Patients with PR-negative breast cancer had significantly worse survival rates compared to those who were PR positive, according to multivariate analysis (hazard ratio = 1.77, 95% confidence interval: 1.01-3.11, = .045); however, there was only a statistically significant difference in postmenopausal patients. The PR was a prognostic factor in postmenopausal women with breast cancer, but not in premenopausal women.
越南女性的乳腺癌知之甚少。之前的研究报告了这一人群中乳腺癌预后因素的频率。本研究旨在研究与在越南国家癌症医院接受治疗的乳腺癌患者生存率相关的预后因素。我们招募了 248 名接受手术和辅助治疗的可手术乳腺癌女性患者。肿瘤组织样本通过多种免疫组织化学方法进行染色，并分析雌激素受体、孕激素受体和基因扩增状态。Cox 模型用于确定生存与预后因素之间的关系。5 年时无病生存率、总生存率和癌症特异性生存率分别为 75.8%、80.6%和 86.4%，10 年时分别为 62.3%、68.1%和 78.9%。肺部是最常见的转移部位。具有不良预后因素（例如，临床分期较晚、肿瘤分级较高、孕激素受体[PR]阴性、基因扩增）的女性生存率显著较低。多因素分析显示，PR 阴性乳腺癌患者的生存率明显低于 PR 阳性患者（危险比=1.77，95%置信区间：1.01-3.11，=0.045）；然而，仅在绝经后患者中存在统计学差异。PR 是绝经后乳腺癌患者的预后因素，但不是绝经前女性的预后因素。
