Department of Cell Biology, Yale School of Medicine, New Haven, CT, USA.
Max Planck Institute of Biochemistry, Martinsried, Germany.
FEBS Lett. 2019 Sep;593(17):2412-2427. doi: 10.1002/1873-3468.13552. Epub 2019 Jul 30.
In eukaryotic cells, the trans-Golgi network (TGN) serves as a platform for secretory cargo sorting and trafficking. In recent years, it has become evident that a complex network of lipid-lipid and lipid-protein interactions contributes to these key functions. This review addresses the role of lipids at the TGN with a particular emphasis on sphingolipids and diacylglycerol. We further highlight how these lipids couple secretory cargo sorting and trafficking for spatiotemporal coordination of protein transport to the plasma membrane.
在真核细胞中，高尔基体反面网络（TGN）充当了分泌货物分拣和运输的平台。近年来，脂质-脂质和脂质-蛋白相互作用的复杂网络对这些关键功能的重要性变得越来越明显。本综述重点介绍了鞘脂类和二酰基甘油在 TGN 中的作用，进一步强调了这些脂质如何将分泌货物分拣和运输偶联起来，以实现蛋白质运输到质膜的时空协调。
