Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India.
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, Punjab, India; GRT Institute of Pharmaceutical Education and Research, GRT Mahalakshmi Nagar, Tiruttani, India.
Eur J Med Chem. 2019 Oct 15;180:562-612. doi: 10.1016/j.ejmech.2019.07.019. Epub 2019 Jul 11.
Heterocycles occupy a salient place in chemistry due to their wide range of activity in the fields of drug design, photochemistry, agrochemicals, dyes, and so on. Amongst all, indole scaffold is considered as one of the most promising heterocycles found in natural and synthetic sources and has been shown to possess various biological activity, including anti-inflammatory, anti-HIV, antitubercular, antimalarial, anticonvulsant, antidiabetic, antihypertensive, analgesics, antidepressant, anticancer, antioxidant, antifungal, and antimicrobial, etc. All the reported indole molecules bind to multiple receptors with high affinity, thus expedite the research on the development of novel biologically active compounds through the various approach. In this review, we aimed to highlight synthetic and medicinal perspective on the development of indole-based analogs. In addition, structural activity relationship (SAR) study to correlate for their biological activity also discussed.
杂环化合物由于在药物设计、光化学、农药、染料等领域的广泛活性而占据着重要的地位。在所有杂环中，吲哚骨架被认为是天然和合成来源中最有前途的杂环之一，并且已显示出具有多种生物活性，包括抗炎、抗 HIV、抗结核、抗疟疾、抗惊厥、抗糖尿病、抗高血压、镇痛药、抗抑郁药、抗癌、抗氧化剂、抗真菌和抗菌等。所有报道的吲哚分子都与多个受体具有高亲和力结合，从而通过各种方法加速了新型生物活性化合物的开发研究。在这篇综述中，我们旨在强调基于吲哚的类似物的合成和药用观点。此外，还讨论了结构活性关系 (SAR) 研究，以将其生物活性相关联。
