根据组织学分类的多发性胃息肉危险因素：前瞻性观察队列研究。

Risk Factors of Multiple Gastric Polyps according to the Histologic Classification: Prospective Observational Cohort Study.

作者信息

Jeong Chan Young, Kim Nayoung, Lee Hye Seung, Yoon Hyuk, Shin Cheol Min, Park Young Soo, Kim Jin-Wook, Lee Dong Ho

机构信息

Department of Internal Medicine, Seoul National University Bundang Hospital, Seoungnam, Korea.

Department of Pathology, Seoul National University Bundang Hospital, Seoungnam, Korea.

出版信息

Korean J Gastroenterol. 2019 Jul 25;74(1):17-29. doi: 10.4166/kjg.2019.74.1.17.

DOI:10.4166/kjg.2019.74.1.17

PMID:31344769

Abstract

BACKGROUND/AIMS: The aim of this study was to determine the risk factors of multiple gastric polyps according to the histological classification of gastric polyps.

METHODS

Subjects with multiple gastric polyps (at least three) during endoscopy were enrolled prospectively. They were assigned to a fundic gland polyp (FGP) group and hyperplastic polyp (HP) group based on a histological classification of gastric polyps. () was confirmed by its histology. Serum gastrin was measured using the radioimmunoassay method. A questionnaire was taken regarding the intake of proton pump inhibitor and nonsteroidal anti-inflammatory drugs, alcohol, smoking history, and diet.

RESULTS

Among the 60 subjects enrolled from 2015 to 2018 at Seoul National University Bungdang Hospital, 47 and 13 subjects were assigned to the FGP and HP groups, respectively. The infection rate was 12.8% in the FGP group, which is lower than that in the HP group (69.2%, p<0.001). The gastrin level was higher in the HP group (194.7 pg/dL, range 50.6-387.8 pg/dL) than in the FGP group (57.4 pg/dL, range 24.8-79.0 pg/dL) (p=0.007). Histologically, neutrophil infiltration in the antrum and body of the stomach were higher in the HP group than in the FGP group (p=0.022 and p=0.030, respectively). In contrast, monocyte infiltration in the antrum and body of the stomach were higher in the FGP group than in the HP group (p=0.018 and p<0.001, respectively).

CONCLUSIONS

HPs arise from inflammation caused by . On the other hand, the FGP was not associated with or environmental factors.

摘要

背景/目的：本研究旨在根据胃息肉的组织学分类确定多发性胃息肉的危险因素。

方法

前瞻性纳入在内镜检查时发现有多发性胃息肉（至少三个）的受试者。根据胃息肉的组织学分类，将他们分为胃底腺息肉（FGP）组和增生性息肉（HP）组。（）通过组织学确诊。采用放射免疫分析法测定血清胃泌素。就质子泵抑制剂和非甾体抗炎药的使用、酒精、吸烟史及饮食情况进行问卷调查。

结果

2015年至2018年在首尔国立大学盆唐医院纳入的60名受试者中，分别有47名和13名受试者被分配至FGP组和HP组。FGP组的感染率为12.8%，低于HP组（69.2%，p<0.001）。HP组的胃泌素水平（194.7 pg/dL，范围50.6 - 387.8 pg/dL）高于FGP组（57.4 pg/dL，范围24.8 - 79.0 pg/dL）（p = 0.007）。组织学上，HP组胃窦和胃体的中性粒细胞浸润高于FGP组（分别为p = 0.022和p = 0.030）。相反，FGP组胃窦和胃体的单核细胞浸润高于HP组（分别为p = 0.018和p<0.001）。