Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska.
J Cell Physiol. 2019 Nov;234(11):19298-19306. doi: 10.1002/jcp.28610. Epub 2019 Apr 4.
The stem cell transcription factor Sox2 is widely recognized for its many roles during normal development and cancer. Over the last several years, it has become increasingly evident that Sox2 dosage plays critical roles in both normal and malignant cells. The work described in this review indicates that the dosage of Sox2 influences cell fate decisions made during normal mammalian development, as well as cell fate decisions in cancer, including those that influence the tumor cell of origin and progression of the cancer. Equally important, Sox2 dosage is a key determinant in the proliferation of both normal cells and tumor cells, where proliferation is restricted in Sox2 cells. Collectively, the studies reviewed here indicate that tumor cells utilize the fundamental effects of Sox2 dosage to suit their own needs. Finally, we speculate that elevated expression of Sox2 helps establish and maintain tumor dormancy in Sox2-positive cancers.
干细胞转录因子 Sox2 在正常发育和癌症中发挥着多种作用，这一点已得到广泛认可。在过去的几年中， Sox2 剂量在正常细胞和恶性细胞中都起着关键作用，这一点变得越来越明显。本综述中描述的工作表明， Sox2 剂量影响正常哺乳动物发育过程中细胞命运的决定，以及癌症中的细胞命运决定，包括那些影响肿瘤细胞起源和癌症进展的决定。同样重要的是， Sox2 剂量是正常细胞和肿瘤细胞增殖的关键决定因素， Sox2 细胞的增殖受到限制。总的来说，这里综述的研究表明，肿瘤细胞利用 Sox2 剂量的基本作用来满足自身的需要。最后，我们推测 Sox2 的高表达有助于 Sox2 阳性癌症中肿瘤休眠的建立和维持。
