Department of Thoracic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
J Cell Physiol. 2019 Nov;234(11):19655-19662. doi: 10.1002/jcp.28565. Epub 2019 Apr 4.
Clinicopathological characteristics and prognosis of esophageal cancer (EC) patients with decreased prognostic nutritional index (PNI) have not been well investigated. So, we conducted this meta-analysis. We performed comprehensive research in PubMed, Embase, and Cochrane databases. The effect size was hazard ratio (HR) with 95% confidence interval (CI) for overall survival (OS) and cancer-specific survival (CSS). The pooled odds ratio (OR) with 95% CI were used to assess the association between PNI and clinicopathological features. A total of 3,425 EC patients were included in the present meta-analysis. Male patients, advanced age, higher tumor stage, and lymph node metastases were associated with reduced PNI level (OR = 1.40, 95% CI: 1.10-1.79; OR = 1.35, 95% CI: 1.10-1.66; OR = 2.37, 95% CI: 1.91-2.94; OR = 1.63, 95% CI: 1.04-2.56). And, the EC patients with decreased PNI held a worse OS and CSS compared with those who carried a higher PNI (HR = 1.29, 95% CI: 1.10-1.50; HR = 2.53, 95% CI: 1.15-5.57). This meta-analysis demonstrated PNI level was associated with tumor stage and lymph nodes metastases and was an independent prognostic factor in EC.
患有预后营养指数（PNI）降低的食管癌（EC）患者的临床病理特征和预后尚未得到很好的研究。因此，我们进行了这项荟萃分析。我们在 PubMed、Embase 和 Cochrane 数据库中进行了全面的研究。使用风险比（HR）及其 95%置信区间（CI）来评估总体生存率（OS）和癌症特异性生存率（CSS）的效应大小。使用汇总优势比（OR）及其 95%CI 来评估 PNI 与临床病理特征之间的关联。本荟萃分析共纳入 3425 名 EC 患者。男性患者、高龄、较高的肿瘤分期和淋巴结转移与较低的 PNI 水平相关（OR=1.40，95%CI：1.10-1.79；OR=1.35，95%CI：1.10-1.66；OR=2.37，95%CI：1.91-2.94；OR=1.63，95%CI：1.04-2.56）。此外，与 PNI 较高的 EC 患者相比，PNI 降低的 EC 患者的 OS 和 CSS 更差（HR=1.29，95%CI：1.10-1.50；HR=2.53，95%CI：1.15-5.57）。这项荟萃分析表明，PNI 水平与肿瘤分期和淋巴结转移有关，是 EC 的一个独立预后因素。
