Department of Stomatology, Tangshan Worker's Hospital, Tangshan, 063000, Hebei, P. R. China.
Department of Emergency, Tangshan Worker's Hospital, Tangshan, 063000, Hebei, P. R. China.
Rev Cardiovasc Med. 2019 Jun 30;20(2):81-89. doi: 10.31083/j.rcm.2019.02.52.
Periodontitis is one of the risk factors associated with peripheral artery disease. This meta-analysis evaluates how periodontitis contributes to the pathogenesis and progression of peripheral artery disease. We systematically searched electronic databases Ovid Medline, Embase, Cochrane Library and Pubmed. Grey literature was also searched via Google Scholar. All studies evaluating the relationship between the incidence of periodontitis and peripheral artery disease were included. Subgroup analyses of carotid artery disease and lower extremity arterial disease were also conducted. Odds ratios (OR) and 95% confidence intervals (CI) were pooled and analyzed. The I² statistic was used to evaluate heterogeneity. Within a total of 25 studies, including 22,090 participants based on eligibility criteria, the incidence of peripheral artery disease was significantly higher among those with periodontitis (OR: 1.60, 95% CI 1.41-1.82, P < 0.001, I² = 80.5%). In subgroup analysis, periodontitis was still a risk for lower extremity arterial disease (OR: 3.00, 95% CI 2.23-4.04, P < 0.001, I² = 0%) and carotid artery disease (OR: 1.39, 95% CI 1.24-1.56, P < 0.001, I² = 79.4%). Periodontitis is significantly associated with the incidence of lower extremity arterial disease and carotid artery disease.
牙周炎是外周动脉疾病的危险因素之一。本荟萃分析评估了牙周炎如何促进外周动脉疾病的发病机制和进展。我们系统地检索了电子数据库 Ovid Medline、Embase、Cochrane 图书馆和 Pubmed。还通过 Google Scholar 搜索了灰色文献。所有评估牙周炎发病率与外周动脉疾病之间关系的研究均被纳入。还进行了颈动脉疾病和下肢动脉疾病的亚组分析。汇总并分析了比值比（OR）和 95%置信区间（CI）。使用 I² 统计量评估异质性。在总共 25 项研究中，根据纳入标准，包括 22090 名参与者，牙周炎患者外周动脉疾病的发病率明显更高（OR：1.60，95%CI 1.41-1.82，P<0.001，I²=80.5%）。在亚组分析中，牙周炎仍然是下肢动脉疾病（OR：3.00，95%CI 2.23-4.04，P<0.001，I²=0%）和颈动脉疾病（OR：1.39，95%CI 1.24-1.56，P<0.001，I²=79.4%）的危险因素。牙周炎与下肢动脉疾病和颈动脉疾病的发病率显著相关。
