Laboratorio de Investigación en Proteínas, Instituto de Química Básica y Aplicada del Nordeste Argentino (UNNECONICET), Facultad de Ciencias Exactas y Naturales y Agrimensura, Corrientes, Argentina.
Laboratorio de Toxicología Veterinaria dependiente de la Cátedra de Farmacología y Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional del Nordeste, Corrientes, Argentina.
Curr Top Med Chem. 2019;19(22):1962-1980. doi: 10.2174/1568026619666190725094851.
Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore, constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.
在栖息于阿根廷东北部的蛇类中，矛头蝮属（Bothrops）的蛇类，如矛头蝮（B. alternatus）和矛头蝮响尾蛇（B. diporus）种（也称为 yararás）以及响尾蛇（Crotalus durisus terrificus）（称为 cascabel），是三十多年来研究最多的蛇毒。这两个毒蛇属占毒蛇咬伤的大多数，因此在该地区构成了医疗紧急情况。本综述广泛描述了有关毒蛇咬伤的综合知识：其病理生理学作用，蛋白质组成，分离的毒素，毒素协同作用，毒素-抗毒素交叉反应测定。一些分离毒素的特性支持潜在的药理学应用。
