Division of Neonatology, University and Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia 46026, Spain.
Department of Pediatric Research, Oslo University Hospital, University of Oslo, Postboks 4950 Nydalen, Oslo 0424, Norway; Department of Pediatrics, Robert H Lurie Medical Research Center, Chicago, IL, USA; Northwestern University, Evanston, IL, USA.
Clin Perinatol. 2019 Sep;46(3):459-473. doi: 10.1016/j.clp.2019.05.013. Epub 2019 Jun 12.
Transition into the extrauterine world is characterized by a substantial increase in oxygen availability to tissue. Exact oxygen provision may be needed to avoid negative consequences of hypoxia or hyperoxia. For term and near-term infants, it is recommended to start with air and titrate the oxygen supplement to the saturation nomogram. However, oxygen supplementation in infants less than 32 weeks' gestation is an unsolved conundrum. At present, the inspired fraction of oxygen is set according to gestational age and blended to achieve targeted saturations and heart rates. Studies are still needed to overcome uncertainties about oxygen supplementation during preterm stabilization.
过渡到宫外世界的特点是组织可获得大量氧气。确切的氧气供应可能是必需的，以避免缺氧或高氧的负面后果。对于足月和近足月的婴儿，建议从空气开始，并根据饱和度图表滴定氧气补充。然而，对于胎龄小于 32 周的婴儿，氧气补充仍然是一个悬而未决的难题。目前，根据胎龄设定吸入氧气分数，并混合以达到目标饱和度和心率。仍需要研究来克服早产儿稳定过程中氧气补充的不确定性。
