Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Indiana University, Riley Hospital for Children at Indiana University Health, 1030 West Michigan Street, C4600, Indianapolis, IN 46202, USA.
Department of Pediatrics, Section of Neonatal-Perinatal Medicine, Indiana University, Riley Hospital for Children at Indiana University Health, 1030 West Michigan Street, C4600, Indianapolis, IN 46202, USA.
Clin Perinatol. 2019 Sep;46(3):517-536. doi: 10.1016/j.clp.2019.05.004. Epub 2019 Jun 20.
Continuous positive airway pressure (CPAP), noninvasive intermittent positive pressure ventilation (NIPPV), and heated humidified high-flow nasal cannula (HHFNC) are modes of noninvasive respiratory support used in neonatal practice. These modes of noninvasive respiratory support may obviate mechanical ventilation, prevent extubation failure, and reduce the risk of developing bronchopulmonary dysplasia. Although the physiologic bases of CPAP and HHFNC are well delineated, and their modes and practical application consistent, those of NIPPV are unproven and varied. Available evidence suggests that NIPPV is superior to CPAP as a primary and postextubation respiratory support in preterm infants.
持续气道正压通气（CPAP）、无创间歇正压通气（NIPPV）和加热湿化高流量鼻导管（HHFNC）是新生儿临床中使用的非侵入性呼吸支持模式。这些非侵入性呼吸支持模式可避免机械通气、预防拔管失败，并降低发生支气管肺发育不良的风险。尽管 CPAP 和 HHFNC 的生理基础已经得到很好的描述，并且它们的模式和实际应用也一致，但 NIPPV 的基础尚未得到证实，并且模式多样。现有证据表明，NIPPV 作为早产儿的主要和拔管后呼吸支持手段优于 CPAP。
