温热湿化高流量鼻导管作为治疗新生儿呼吸窘迫综合征初始通气方法的安全性和有效性：一项系统评价与荟萃分析方案
The safety and effectiveness of heated humidified high-flow nasal cannula as an initial ventilation method in the treatment of neonatal respiratory distress syndrome: A protocol for systematic review and meta-analysis.
作者信息
Li Shu-Ni, Li Li, Li Chun-Lei, Zhou Shu-Ping, Lu Wei-Cheng
机构信息
Department of Nursing.
Department of Pediatrics Area One.
出版信息
Medicine (Baltimore). 2020 Nov 13;99(46):e23243. doi: 10.1097/MD.0000000000023243.
BACKGROUND
This study uses a method of systematic evaluation to evaluate the safety and effectiveness of heated humidified high-flow nasal cannula (HHHFNC) as an initial ventilation method in the treatment of neonatal respiratory distress syndrome (NRDS) scientifically. In the field of evidence-based medicine, this study provides a theoretical reference and basis for choosing appropriate initial non-invasive ventilation methods in the treatment of NRDS, thereby providing assistance for clinical treatment.
METHODS
The main electronic network databases were searched by computer, including 4 Chinese databases: CNKI, WangFang Data, CQVIP, SinoMed and 3 English databases: PubMed, The Cochrane Library and EMBASE, the time range of retrieval from the beginning of each database to September 1, 2020. The content involves all the published randomized controlled trials on the effectiveness of HHHFNC compared with NCPAP as an initial ventilation method in the treatment of NRDS. Using a search method that combines medical subject words and free words. Based on the Cochrane risk bias assessment tool, 2 researchers independently screen the literature, and then extract the data we needed in the literature, and cross-check. If it is difficult to decide whether to include literature, then turning to a third researcher for help and making a final decision after discussion, and using RevMan 5.3 and STATA 13.0 to analyze the relative data.
RESULTS
Based on the method of meta-analysis, this study analyzes the pre-determined outcome indicators through scientific statistical analysis, and compares the effectiveness and safety of HHHFNC compared with NCPAP as an initial ventilation method in the treatment of NRDS. All results will be published in peer-reviewed high-quality professional academic journals.
CONCLUSION
Based on evidence-based medicine, this study will obtain the establishing evidence of comparison that the clinical effectiveness and safety of HHHFNC compared with NCPAP as an initial ventilation method in the treatment of NRDS through the existing data and data, which provides the evidence support of evidence-based medicine in the treatment of NRDS.
OSF REGISTRATION NUMBER
September 17, 2020. osf.io/f6at4 (https://osf.io/f6at4).
背景
本研究采用系统评价方法，科学评估加热湿化高流量鼻导管（HHHFNC）作为初始通气方式治疗新生儿呼吸窘迫综合征（NRDS）的安全性和有效性。在循证医学领域，本研究为NRDS治疗中选择合适的初始无创通气方式提供理论参考和依据，从而为临床治疗提供帮助。
方法
通过计算机检索主要电子网络数据库，包括4个中文数据库：中国知网、万方数据、维普资讯、中国生物医学文献数据库，以及3个英文数据库：PubMed、考克兰图书馆、EMBASE，检索时间范围为各数据库建库至2020年9月1日。内容涉及所有已发表的关于HHHFNC与鼻塞持续气道正压通气（NCPAP）作为初始通气方式治疗NRDS有效性的随机对照试验。采用医学主题词与自由词相结合的检索方法。基于考克兰风险偏倚评估工具，2名研究人员独立筛选文献，然后提取文献中所需的数据，并进行交叉核对。若难以决定是否纳入文献，则求助于第三名研究人员，经讨论后做出最终决定，并使用RevMan 5.3和STATA 13.0对相关数据进行分析。
结果
本研究基于Meta分析方法，通过科学的统计分析对预先设定的结局指标进行分析，比较HHHFNC与NCPAP作为初始通气方式治疗NRDS的有效性和安全性。所有结果将发表在同行评议的高质量专业学术期刊上。
结论
基于循证医学，本研究将通过现有数据和资料获得HHHFNC与NCPAP作为初始通气方式治疗NRDS临床有效性和安全性比较的确证证据，为NRDS治疗提供循证医学的证据支持。
开放科学框架注册号
2020年9月17日。osf.io/f6at4（https://osf.io/f6at4）
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