BHF Centre for Cardiovascular Science, University of Edinburgh, 47 Little France Crescent, Edinburgh, United Kingdom.
Department of Cardiology, VU University Medical Centre, de Boelelaan 1117, 1081, HV, Amsterdam, the Netherlands.
J Cardiovasc Comput Tomogr. 2019 Sep-Oct;13(5):242-247. doi: 10.1016/j.jcct.2019.07.002. Epub 2019 Jul 17.
Despite decades of research and major innovations in technology, cardiovascular disease remains the leading cause of death globally. Our understanding of major cardiovascular events and their prevention is centred around the atherosclerotic plaque and the processes that ultimately lead to acute plaque rupture. Recent advances in hybrid imaging technology allow the combination of high spatial resolution and anatomical detail with molecular assessments of disease activity. This provides the ability to identify vulnerable plaque characteristics and differentiate active and quiescent disease, with the potential to improve patient risk stratification. Combined positron emission tomography and computed tomography is the prototypical non-invasive hybrid imaging technique for coronary artery plaque assessment. In this review we discuss the current state of play in the field of hybrid coronary atherosclerosis imaging.
尽管几十年来在医学研究和技术创新方面取得了重大进展，但心血管疾病仍然是全球主要的死亡原因。我们对主要心血管事件及其预防的理解主要集中在动脉粥样硬化斑块及其最终导致急性斑块破裂的过程上。最近混合成像技术的进步允许将高空间分辨率和解剖细节与疾病活动的分子评估相结合。这提供了识别易损斑块特征和区分活跃和静止疾病的能力，有可能改善患者的风险分层。正电子发射断层扫描和计算机断层扫描是典型的用于冠状动脉斑块评估的非侵入性混合成像技术。在这篇综述中，我们讨论了混合冠状动脉粥样硬化成像领域的当前现状。
