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日本电子株式会社(JEOL)、核磁共振(NMR)和电子顺磁共振(ESR):65 年的发展历程。

JEOL, NMR and ESR: A 65 year evolution.

机构信息

NM Group SI Sales Promotion Department JEOL Ltd., Otemachi Nomura Bldg. 13F, 2-1-1, Otemachi, Chiyoda, Tokyo 100-0004, Japan.

出版信息

J Magn Reson. 2019 Sep;306:17-26. doi: 10.1016/j.jmr.2019.07.033. Epub 2019 Jul 16.

Abstract

Felix Bloch and Edward Purcell successfully detected NMR signals in 1946, and VARIAN was the first company in the world to complete a commercial product in 1950. JEOL released their first commercial NMR instrument 6 years later. At that time, the magnetic field intensity was 30-40 MHz, so the ability to separate signals was extremely low. The users of NMR wanted higher magnetic fields, and the key issue for NMR manufacturers became how to increase the magnetic field strength. With a permanent magnet, the maximum magnetic field is 90 MHz (2.11 Tesla), and the limit with an electromagnet is 100 MHz (2.4 Tesla). This limitation was removed with the advent of superconducting magnets (SCM). Furthermore, in addition to the Continuous Wave method, which only allowed observation of 1H nuclei, Pulse Fourier Transform (FT) methods were developed, enabling observation and measurement of 13C and other nuclei. The development of SCM and FT was epoch-making for NMR, and the field has flourished since then. Of course, there has been technical innovation that could not be accomplished by the NMR manufacturers alone, such as the development of superconducting materials and winding techniques for SCM, and new algorithm development and the acceleration of computing speeds for FT. This report will relate the story of NMR, including these developments that have provided the background.

摘要

费利克斯·布洛赫和爱德华·珀塞尔于 1946 年成功检测到 NMR 信号,瓦里安公司于 1950 年成为世界上第一家完成商业产品的公司。JEOL 于 6 年后发布了他们的第一台商业 NMR 仪器。当时,磁场强度为 30-40MHz,因此信号分离能力极低。NMR 的使用者希望磁场强度更高,NMR 制造商的关键问题是如何提高磁场强度。使用永磁体,最大磁场为 90MHz(2.11特斯拉),电磁体的极限为 100MHz(2.4 特斯拉)。超导磁体(SCM)的出现消除了这一限制。此外,除了只能观察 1H 核的连续波方法外,还开发了脉冲傅里叶变换(FT)方法,能够观察和测量 13C 和其他核。SCM 和 FT 的发展对 NMR 来说是划时代的,从那时起,该领域蓬勃发展。当然,也有一些技术创新是 NMR 制造商单独无法完成的,例如超导材料的开发和 SCM 的绕组技术,以及 FT 的新算法开发和计算速度的加速。本报告将讲述 NMR 的故事,包括这些为其提供背景的发展。

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