Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Sci Rep. 2019 Jul 25;9(1):10816. doi: 10.1038/s41598-019-47367-2.
Recent evidence has indicated that the lymphatic vessel endothelial hyaluronan receptor (LYVE-1) is implicated in chronic inflammation and the lymphatic immune response. The soluble form of LYVE-1 (sLYVE-1) is produced by ectodomain shedding of LYVE-1 under pathological conditions including cancer and chronic inflammation. In this study, 1014 consecutive patients who underwent coronary angiography from May 2015 to September 2015 were included to investigate whether serum sLYVE-1 is associated with coronary artery disease (CAD) and its concomitant diseases includes chronic kidney disease (CKD). Results showed that there was no significant difference in sLYVE-1 levels between patients with CAD and without. However, a significantly higher level of sLYVE-1 was seen in patients with renal dysfunction compared to those with a normal eGFR. Results were validated in a separate cohort of 259 patients who were divided into four groups based on their kidney function assessed by estimated glomerular filtration rate (eGFR). Simple bivariate correlation analysis revealed that Lg[sLYVE-1] was negatively correlated with eGFR (r = -0.358, p < 0.001) and cystatin C (r = 0.303, p < 0.001). Multivariable logistic regression analysis revealed that the increase in Lg[sLYVE-1] was an independent determinant of renal dysfunction (odds ratio = 1.633, p = 0.007). Therefore, renal function should be considered when serum sLYVE-1 is used as a biomarker for the detection of pathological conditions such as chronic inflammation and cancer. Further study is required to elucidate the exact role of sLYVE-1 in renal function.
最近的证据表明，淋巴管内皮透明质酸受体（LYVE-1）参与慢性炎症和淋巴免疫反应。LYVE-1 的可溶性形式（sLYVE-1）是在包括癌症和慢性炎症在内的病理条件下通过 LYVE-1 的外显子脱落产生的。在这项研究中，纳入了 1014 名连续接受冠状动脉造影的患者，这些患者于 2015 年 5 月至 2015 年 9 月进行，以调查血清 sLYVE-1 是否与冠状动脉疾病（CAD）及其合并症（包括慢性肾脏病（CKD））相关。结果显示，CAD 患者与非 CAD 患者的 sLYVE-1 水平无显著差异。然而，与 eGFR 正常的患者相比，肾功能障碍患者的 sLYVE-1 水平明显升高。在另一项纳入 259 名患者的独立队列中验证了这些结果，这些患者根据肾小球滤过率（eGFR）评估的肾功能分为四组。简单的双变量相关分析显示，Lg[sLYVE-1]与 eGFR（r=-0.358，p<0.001）和胱抑素 C（r=-0.303，p<0.001）呈负相关。多变量逻辑回归分析显示，Lg[sLYVE-1]的增加是肾功能障碍的独立决定因素（比值比=1.633，p=0.007）。因此，在将血清 sLYVE-1 用作慢性炎症和癌症等病理状况的生物标志物时，应考虑肾功能。需要进一步研究以阐明 sLYVE-1 在肾功能中的确切作用。
