Trudinger B J, Stewart G J, Cook C M, Connelly A, Exner T
Department of Obstetrics and Gynecology, University of Sydney at Westmead Hospital, NSW, Australia.
Obstet Gynecol. 1988 Aug;72(2):215-8.
The presence of the "lupus anticoagulant" in maternal blood is associated with thrombosis in the placental vessels and a high rate of fetal loss. We followed six pregnancies in four mothers positive for lupus anticoagulant autoantibody with Doppler umbilical flow studies. The women were not treated with any drugs, and clinical management was guided by close fetal surveillance including umbilical flow studies. Umbilical artery flow velocity waveforms detect vascular abnormalities in the fetal umbilical placental circulation and were used as an early indicator of developing disease. All pregnancies produced live-born infants. These cases indicate the potential value of such studies in the management of this group at high risk of fetal loss.
母体血液中“狼疮抗凝物”的存在与胎盘血管血栓形成及高胎儿丢失率相关。我们对四名狼疮抗凝物自身抗体阳性母亲的六次妊娠进行了多普勒脐血流研究随访。这些女性未接受任何药物治疗，临床管理以包括脐血流研究在内的密切胎儿监测为指导。脐动脉血流速度波形可检测胎儿脐胎盘循环中的血管异常，并被用作疾病发展的早期指标。所有妊娠均产出活婴。这些病例表明此类研究在管理这一高胎儿丢失风险群体中的潜在价值。
