Southern Medical University, Guangzhou, 510515, China.
Department of Minimally Invasive Spinal Surgery, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010030, China.
Curr Med Sci. 2019 Aug;39(4):597-603. doi: 10.1007/s11596-019-2079-2. Epub 2019 Jul 25.
Improving the closure effect of surgical suture for repair of annulus fibrosus defects remains an unsolved problem. A new type of porcine fibrin glue was reported for the repair of annulus fibrous defects in sheep models in this study. Continuous axial loading test showed that this glue could effectively improve the closure effect of surgical suture for annulus fibrous defect. Magnetic resonance imaging (MRI) of the lumbar spine confirmed that, compared with non-fibrin glue treated intervertebral discs, it contributed to preservation of the nucleus pulposus and maintained the physiological hydration of the intervertebral discs. Moreover, histomorphology evaluation showed that the porcine fibrin glue could partially reverse degeneration of the injured intervertebral discs. Taken together, porcine fibrin glue can effectively enhance the closure effect of surgical suture on annulus fibrosus, improve the repair effect and slow down the degeneration of the intervertebral disc, and provide a potential therapeutic strategy for degenerative intervertebral disc disease.
提高手术缝线修复纤维环缺陷的闭合效果仍然是一个未解决的问题。本研究报道了一种新型猪纤维蛋白胶，用于修复绵羊模型的纤维环纤维缺陷。连续轴向加载试验表明，该胶体能有效提高手术缝线对纤维环缺陷的闭合效果。腰椎磁共振成像（MRI）证实，与未用纤维蛋白胶处理的椎间盘相比，它有助于保护髓核并保持椎间盘的生理水合作用。此外，组织形态学评价表明，猪纤维蛋白胶可部分逆转损伤椎间盘的退变。综上所述，猪纤维蛋白胶能有效增强手术缝线对纤维环的闭合效果，提高修复效果，减缓椎间盘退变，为退行性椎间盘疾病提供一种潜在的治疗策略。
