Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy , China Pharmaceutical University , 24 Tong Jia Xiang , Nanjing 210009 , People's Republic of China.
J Nat Prod. 2019 Aug 23;82(8):2087-2093. doi: 10.1021/acs.jnatprod.8b00815. Epub 2019 Jul 26.
Two uncommon C heterodimeric diterpenoids, taicrypnacids A () and B (), and a known labdane-type diterpenoid () were isolated from the leaves of . Several techniques, such as comprehensive spectroscopic analysis, chemical conversion, X-ray crystallography, and ECD data, were employed to define the structures. The two new compounds displayed cytotoxicity against human breast cancer (MCF-7), osteosarcoma (U-2 OS), and human colon carcinoma (HCT-116) cell lines, while the methyl ester showed no activity. Compound induced Ca-ROS pathway-mediated endoplasmic reticulum stress, and excessive stress led to cell death by activating apoptosis and autophagy.
从 Taicrypna parvifolia 的叶子中分离得到两种不常见的 C 型二萜类化合物，taicrypnacids A()和 B()，以及一种已知的拉伯烷型二萜类化合物()。采用综合光谱分析、化学转化、X 射线晶体学和 ECD 数据等多种技术确定了这些化合物的结构。这两种新化合物对人乳腺癌（MCF-7）、骨肉瘤（U-2 OS）和人结肠癌细胞系（HCT-116）表现出细胞毒性，而甲酯()则没有活性。化合物诱导 Ca-ROS 通路介导的内质网应激，过度应激通过激活细胞凋亡和自噬导致细胞死亡。
