来自翠柏中的拉伯烷二萜和木脂素。

Labdane diterpenoids and lignans from Calocedrus macrolepis.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.

出版信息

Fitoterapia. 2013 Mar;85:154-60. doi: 10.1016/j.fitote.2013.01.011. Epub 2013 Jan 23.

DOI:10.1016/j.fitote.2013.01.011

PMID:23353657

Abstract

Three new labdane diterpenoids, calomacrins A-C (1-3), and a new diaryl butyrolactone-type lignan, calomacrol A (8), as well as four known labdane diterpenoids and six known lignans, were isolated from the twigs and leaves of Calocedrus macrolepis. Structures of the new compounds were elucidated on the basis of their spectroscopic methods, including 1D and 2D NMR techniques. Compounds 3-14 were evaluated for cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cell lines.

摘要

从翠柏的嫩枝和叶片中分离得到三个新的角鲨烷二萜，即 calomacrins A-C（1-3），以及一个新的二芳基丁内酯型木脂素 calomacrol A（8），此外还有四个已知的角鲨烷二萜和六个已知的木脂素。基于光谱学方法，包括 1D 和 2D NMR 技术，解析了这些新化合物的结构。对化合物 3-14 进行了细胞毒性评价，针对 HL-60、SMMC-7721、A-549、MCF-7 和 SW480 细胞系进行了测试。