Wang Wen-Li, Zhu Dong-Rong, Li Ling-Nan, Liu Xiao-Qin, Zhu Li, Zhu Tian-Yu, Chen Chen, Han Chao, Ying Pin, Lin Zhi-Hua, Luo Jian-Guang, Kong Ling-Yi
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing, 210009, P. R. China.
Lishui University, Lishui, 323000, P. R. China.
Chem Biodivers. 2023 Feb;20(2):e202201067. doi: 10.1002/cbdv.202201067. Epub 2023 Jan 18.
Taiwania cryptomerioides Hayata is an endangered relict plant belonging to Taxodiaceae, and it is also an endemic plant to China. The decay-resistant of Taiwania timber can provide highly quality wood for building and furniture. Plenty of regenerative of leaves of T. cryptomerioides also has been used as a resource for the discovery of new dimeric diterpenoids. In a search for structurally diverse dimeric diterpenoids and potent bioactive isolates, ten new heterodimeric diterpenoids, taiwaniadducts K-T (1-4, 6, 8-11, and 14), along with five known ones (5, 7, 12, 13, and 15), were isolated from the leaves of T. cryptomerioides. These new compounds were defined by comprehensive spectroscopic analyses, putative biosynthetic pathways, and the values of optical. Biologically, anti-multidrug resistance (MDR) activities of compounds were evaluated. Compounds 4 and 10 exerted a 9.18-fold potentiation effect on bortezmib (BTZ) susceptibility at a tested concentration (20 μM) better than the positive control verapamil. The research of the leaves of T. cryptomerioides not only added the new data to the structural diversity and activities of dimeric diterpenoids but also could provide support for the medical and industrial application of the leaves of this endangered relict plant.
台湾杉是一种属于杉科的濒危孑遗植物，也是中国的特有植物。台湾杉木材的抗腐性可为建筑和家具提供优质木材。台湾杉大量可再生的叶子也已被用作发现新的二聚二萜类化合物的资源。为了寻找结构多样的二聚二萜类化合物和具有强生物活性的分离物，从台湾杉的叶子中分离出了10种新的杂二聚二萜类化合物，即台湾杉加合物K - T（1 - 4、6、8 - 11和14），以及5种已知化合物（5、7、12、13和15）。这些新化合物通过综合光谱分析、推测的生物合成途径和旋光值来确定。在生物学方面，评估了这些化合物的抗多药耐药（MDR）活性。在测试浓度（20 μM）下，化合物4和10对硼替佐米（BTZ）敏感性的增强作用比阳性对照维拉帕米高9.18倍。对台湾杉叶子的研究不仅为二聚二萜类化合物的结构多样性和活性增添了新数据，还可为这种濒危孑遗植物叶子的医学和工业应用提供支持。
