Chen Huiling, Zhao Meidan, Li Xiuming, Zhang Yanhong, Hao Yu, Xiao Ergang, Gao Wenyuan, Wang Hongwu
School of Pharmaceutical Science and Technology, Tianjin University, Nankai.
College of Health Science and Engineering, Tianjin University of Traditional Chinese Medicine, Healthy Industrial Park, Jinghai.
Medicine (Baltimore). 2019 Jul;98(30):e16477. doi: 10.1097/MD.0000000000016477.
Traditional Chinese medicine (TCM) therapy is effective for post-stroke depression (PSD). TCM therapy encompasses various forms of practices. However, the comparative effectiveness of these therapies is still not clear. Here, we provide a network meta-analysis protocol to compare the effects of different types of TCM therapy on PSD, using both direct and indirect evidence.
Twelve databases investigation will be conducted through the keywords from their inception to June 1, 2019. At least 2 independent reviewers will identify eligible articles. EndNote X7 software is utilized to manage the literatures and RevMan V.5.3 (The Cochrane Collaboration) software is for data processing throughout the review. The package "netmeta" (version 0.5-0) in R (version 3.0.2, The R Foundation for Statistical Computing) will be used to perform network meta-analysis (NMA). In addition, the overall quality of evidence is evaluated by GRADEPro software, and Cochrane Collaboration Risk of Bias Tool is employed for the methodological quality. Generally speaking, this review protocol is reported according to the preferred reporting items for systematic review and meta-analysis protocols 2015 guidelines.
According to this protocol, it will provide evidence in support of, or against, the hypothesis that TCM therapy for PSD is more effective than pharmacotherapy. The results of this study will also provide evidence on relative efficacy of different forms of TCM. Furthermore, this analysis will show which form(s) of TCM therapy is (are) the most effective.
The results will help PSD doctors and patients choose the treatment regimen which is effective, time-saving and economical.
CRD42016041594.
中医治疗对中风后抑郁症（PSD）有效。中医治疗包含多种形式的疗法。然而，这些疗法的相对疗效仍不明确。在此，我们提供一项网状Meta分析方案，以使用直接和间接证据比较不同类型中医治疗对PSD的疗效。
将通过从建库至2019年6月1日的关键词对12个数据库进行检索。至少2名独立评审员将识别符合条件的文章。使用EndNote X7软件管理文献，整个综述过程使用RevMan V.5.3（Cochrane协作网）软件进行数据处理。将使用R（版本3.0.2，R统计计算基金会）中的“netmeta”包（版本0.5 - 0）进行网状Meta分析（NMA）。此外，使用GRADEPro软件评估证据的总体质量，采用Cochrane协作网偏倚风险工具评估方法学质量。一般来说，本综述方案是根据系统评价和Meta分析方案的首选报告项目2015指南进行报告的。
根据本方案，将提供支持或反对中医治疗PSD比药物治疗更有效的假设的证据。本研究结果还将提供不同形式中医治疗相对疗效的证据。此外，该分析将显示哪种形式的中医治疗最有效。
研究结果将有助于PSD医生和患者选择有效、省时且经济的治疗方案。
PROSPERO注册号：CRD42016041594。
