2型糖尿病控制不佳但无糖尿病相关并发症进展且晚期糖基化终产物水平较低：一例报告

Poorly controlled type 2 diabetes with no progression of diabetes-related complications and low levels of advanced glycation end products: A Case report.

作者信息

Nakamura Tomoka, Tsujimoto Tetsuro, Yasuda Kazuki, Chujo Daisuke, Ohsugi Mitsuru, Tanabe Akiyo, Ueki Kohjiro, Kajio Hiroshi

机构信息

Department of Diabetes, Endocrinology, and Metabolism, Center Hospital.

Department of Metabolic Disorders, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine.

出版信息

Medicine (Baltimore). 2019 Jul;98(30):e16573. doi: 10.1097/MD.0000000000016573.

RATIONALE

Previous studies have suggested that increased levels of advanced glycation end products (AGEs) and soluble receptor for AGE (sRAGE) are associated with diabetes-related complications. However, there is little evidence on the association between long-term levels of AGEs and sRAGE and progression of diabetes-related complications.

PATIENT CONCERNS

A 64-year-old man had poorly controlled type 2 diabetes, obesity, smoking, hypertension, and dyslipidemia. He had many risk factors for diabetes-related complications.

DIAGNOSIS

Despite poor glycemic control over 15 years, the patient did not exhibit diabetes-related complications.

INTERVENTIONS

We examined serum AGEs (CEL and MG-H1) and sRAGE levels in this patient over the past 10 years.

OUTCOMES

The patient maintained low serum AGEs and sRAGE levels.

LESSONS

AGEs and sRAGE levels may be associated with long-term development of diabetes-related complications.

理论依据

先前的研究表明，晚期糖基化终产物（AGEs）水平升高以及AGEs可溶性受体（sRAGE）与糖尿病相关并发症有关。然而，关于AGEs和sRAGE的长期水平与糖尿病相关并发症进展之间的关联，证据很少。

患者情况

一名64岁男性，2型糖尿病控制不佳，伴有肥胖、吸烟、高血压和血脂异常。他有许多糖尿病相关并发症的危险因素。

诊断

尽管15年来血糖控制不佳，但该患者未出现糖尿病相关并发症。

干预措施

我们检测了该患者过去10年的血清AGEs（CEL和MG-H1）及sRAGE水平。

结果

该患者血清AGEs和sRAGE水平维持在较低水平。

经验教训

AGEs和sRAGE水平可能与糖尿病相关并发症的长期发展有关。