Nakamura Tomoka, Tsujimoto Tetsuro, Yasuda Kazuki, Chujo Daisuke, Ohsugi Mitsuru, Tanabe Akiyo, Ueki Kohjiro, Kajio Hiroshi
Department of Diabetes, Endocrinology, and Metabolism, Center Hospital.
Department of Metabolic Disorders, Diabetes Research Center, Research Institute, National Center for Global Health and Medicine.
Medicine (Baltimore). 2019 Jul;98(30):e16573. doi: 10.1097/MD.0000000000016573.
Previous studies have suggested that increased levels of advanced glycation end products (AGEs) and soluble receptor for AGE (sRAGE) are associated with diabetes-related complications. However, there is little evidence on the association between long-term levels of AGEs and sRAGE and progression of diabetes-related complications.
A 64-year-old man had poorly controlled type 2 diabetes, obesity, smoking, hypertension, and dyslipidemia. He had many risk factors for diabetes-related complications.
Despite poor glycemic control over 15 years, the patient did not exhibit diabetes-related complications.
We examined serum AGEs (CEL and MG-H1) and sRAGE levels in this patient over the past 10 years.
The patient maintained low serum AGEs and sRAGE levels.
AGEs and sRAGE levels may be associated with long-term development of diabetes-related complications.
先前的研究表明，晚期糖基化终产物（AGEs）水平升高以及AGEs可溶性受体（sRAGE）与糖尿病相关并发症有关。然而，关于AGEs和sRAGE的长期水平与糖尿病相关并发症进展之间的关联，证据很少。
一名64岁男性，2型糖尿病控制不佳，伴有肥胖、吸烟、高血压和血脂异常。他有许多糖尿病相关并发症的危险因素。
尽管15年来血糖控制不佳，但该患者未出现糖尿病相关并发症。
我们检测了该患者过去10年的血清AGEs（CEL和MG-H1）及sRAGE水平。
该患者血清AGEs和sRAGE水平维持在较低水平。
AGEs和sRAGE水平可能与糖尿病相关并发症的长期发展有关。
