糠酸莫米松治疗鼻息肉的疗效：一项随机对照试验系统评价方案
Efficacy of mometasone furoate for nasal polyps: A protocol for systematic review of randomized controlled trial.
作者信息
Yu Hai-Jiang, Han Lin, Wang Wei-Feng, Yang Lin-Hong, Nie Yu-Fei
机构信息
Department of Otorhinolaryngology, First Affiliated Hospital of Jiamusi University.
Department of Ear-Nose-Throat, The 963rd Hospital of the Joint Logistic Support Force of the Chinese People's Liberation Army.
出版信息
Medicine (Baltimore). 2019 Jul;98(30):e16632. doi: 10.1097/MD.0000000000016632.
BACKGROUND
This study aims to systematically explore the efficacy and safety of mometasone furoate (MTF) for patients with nasal polyps (NP).
METHODS
We will search MEDLINE, Cochrane Library, PubMed, Springer, Web of Science, Ovid, Wangfang and Chinese Biomedical Literature Database from their inception to April 30, 2019 without language restrictions. All randomized controlled trials (RCTs) of MTF for the treatment of NP will be considered for inclusion. RevMan 5.3 software will be used for data synthesis, subgroup analysis, sensitivity analysis, as well as the meta-analysis.
RESULTS
Primary outcomes include change in symptom scores (as measured by any symptom scores), and polyp size (as assessed by any Polyp size scores or tools). Secondary outcomes consist of polyp recurrence, change in nasal air flow, quality of life outcomes (as measured by any quality of life scales, such as Short Form Health Survey is a 36-item), and adverse events.
CONCLUSION
This study will provide evidence for judging whether MTF is an effective and safe treatment for NP or not.
PROSPERO REGISTRATION NUMBER
PROSPERO CRD42019134037.
背景
本研究旨在系统探讨糠酸莫米松（MTF）治疗鼻息肉（NP）患者的疗效和安全性。
方法
我们将检索MEDLINE、Cochrane图书馆、PubMed、Springer、科学网、Ovid、万方和中国生物医学文献数据库，检索时间从建库至2019年4月30日，无语言限制。所有MTF治疗NP的随机对照试验（RCT）均考虑纳入。将使用RevMan 5.3软件进行数据合成、亚组分析、敏感性分析以及荟萃分析。
结果
主要结局包括症状评分的变化（通过任何症状评分测量）和息肉大小（通过任何息肉大小评分或工具评估）。次要结局包括息肉复发、鼻气流变化、生活质量结局（通过任何生活质量量表测量，如简短健康调查问卷是一个36项的量表）和不良事件。
结论
本研究将为判断MTF是否为NP的有效和安全治疗方法提供证据。
PROSPERO注册号：PROSPERO CRD42019134037。
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