磁共振信号强度与锰暴露工人的帕金森病。
MRI Signal Intensity and Parkinsonism in Manganese-Exposed Workers.
机构信息
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri (Dr Criswell, Dr Nielsen, Mr Warden, Mr Flores, Mr Lenox-Krug, Ms Racette, and Dr Racette); Department of Environmental and Occupational Health Sciences, University of Washington, School of Public Health, Seattle, Washington (Dr Sheppard); Department of Biostatistics, University of Washington, School of Public Health, Seattle, Washington (Dr Sheppard); Department of Family Medicine and Public Health, UC San Diego School of Medicine, La Jolla, California (Dr Checkoway); Department of Neurosciences, UC San Diego School of Medicine, La Jolla, California (Dr Checkoway); School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Parktown, South Africa (Dr Racette).
出版信息
J Occup Environ Med. 2019 Aug;61(8):641-645. doi: 10.1097/JOM.0000000000001634.
OBJECTIVE
T1-weighted brain magnetic resonance imaging (MRI) of the basal ganglia provides a noninvasive measure of manganese (Mn) exposure, and may also represent a biomarker for clinical neurotoxicity.
METHODS
We acquired T1-weighted MRI scans in 27 Mn-exposed welders, 12 other Mn-exposed workers, and 29 nonexposed participants. T1-weighted intensity indices were calculated for four basal ganglia regions. Cumulative Mn exposure was estimated from work history data. Participants were examined using the Unified Parkinson's Disease Rating Scale motor subsection 3 (UPDRS3).
RESULTS
We observed a positive dose-response association between cumulative Mn exposure and the pallidal index (PI) (β = 2.33; 95% confidence interval [CI], 0.93 to 3.74). There was a positive relationship between the PI and UPDRS3 (β = 0.15; 95% CI, 0.03 to 0.27).
CONCLUSION
The T1-weighted pallidal signal is associated with occupational Mn exposure and severity of parkinsonism.
目的
基底节区 T1 加权脑磁共振成像（MRI）可提供非侵入性的锰（Mn）暴露测量方法，也可能是临床神经毒性的生物标志物。
方法
我们对 27 名 Mn 暴露焊工、12 名其他 Mn 暴露工人和 29 名未暴露参与者进行了 T1 加权 MRI 扫描。计算了四个基底节区的 T1 加权强度指数。累积 Mn 暴露量根据工作史数据进行估算。使用统一帕金森病评定量表运动部分 3（UPDRS3）对参与者进行检查。
结果
我们观察到累积 Mn 暴露与苍白球指数（PI）之间存在正剂量反应关系（β=2.33；95%置信区间 [CI]，0.93 至 3.74）。PI 与 UPDRS3 之间存在正相关关系（β=0.15；95% CI，0.03 至 0.27）。
结论
T1 加权苍白球信号与职业性 Mn 暴露和帕金森病严重程度有关。
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