特比萘芬对曲霉属临床分离株的最低抑菌浓度及杀菌活性
MIC and fungicidal activity of terbinafine against clinical isolates of Aspergillus spp.
作者信息
Schmitt H J, Bernard E M, Andrade J, Edwards F, Schmitt B, Armstrong D
机构信息
Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
出版信息
Antimicrob Agents Chemother. 1988 May;32(5):780-1. doi: 10.1128/AAC.32.5.780.
Abstract
Terbinafine and amphotericin B MICs for 90% of strains tested were 1.6 and 0.4 micrograms/ml against Aspergillus fumigatus (16 strains), 0.8 and 3.2 micrograms/ml against Aspergillus flavus (10 strains), and 0.4 and 1.6 micrograms/ml against Aspergillus niger (10 strains), respectively. For all species tested, the minimal inhibitory and fungicidal concentrations for 90% of strains of both drugs were identical and the inoculum size did not have a major effect on the results.
摘要
对于90%的受试菌株，特比萘芬和两性霉素B对烟曲霉（16株）的最低抑菌浓度分别为1.6微克/毫升和0.4微克/毫升，对黄曲霉（10株）的最低抑菌浓度分别为0.8微克/毫升和3.2微克/毫升，对黑曲霉（10株）的最低抑菌浓度分别为0.4微克/毫升和1.6微克/毫升。对于所有受试菌种，两种药物对90%菌株的最低抑菌浓度和最低杀菌浓度相同，接种量对结果没有重大影响。
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