Punjani Nahid, Nayan Madhur, Jarvi Keith, Lo Kirk, Lau Susan, Grober Ethan D
Division of Urology, Western University, London, ON, Canada.
Division of Urology, University of Toronto, Toronto, ON, Canada.
Can Urol Assoc J. 2020 Feb;14(2):31-35. doi: 10.5489/cuaj.5897. Epub 2019 Jul 23.
We aimed to study the association of ethnicity on semen parameters and hormones in patients presenting with infertility.
Data from men presenting for infertility assessment were prospectively collected and retrospectively reviewed. Demographic and clinical history was self-reported. Semen analysis included volume, count, motility, morphology, and vitality. The 2010 World Health Organization cutoffs were used. Baseline total testosterone and follicle-stimulating hormone (FSH) levels were recorded. Ethnicity data was classified as Caucasian, African Canadian, Asian, Indo-Canadian, Native Canadian, Hispanic, and Middle Eastern. All patients with complete data were included and statistical analysis was performed.
A total of 9079 patients were reviewed, of which 3956 patients had complete data. Of these, 839 (21.2%) were azoospermic. After adjusting for age, African Canadians (odds ratio [OR] 1.70; 95% confidence interval [CI] 1.28-2.25) and Asians (1.34; 95% CI 1.11-1.62) were more likely to be azoospermic compared to Caucasians. Similarly, African Canadians (OR 1.75; 95% CI 1.33-2.29) were more likely to be oligospermic and Asians (OR 0.82; 95% CI 0.70-0.97) less likely to be oligospermic. Low volume was found in African Canadian (OR 1.42; 95% CI 1.05-1.91), Asians (OR 1.23; 95% CI 1.01-1.51), and Indo-Canadians (OR 1.47; 95% CI 1.01-2.13). Furthermore, Asians (OR 0.73; 95% CI 0.57-0.93) and Hispanics (OR 0.58; 95% CI 034-0.99) were less likely to have asthenospermia. Asians (OR 0.73; 95% CI 0.57-0.94) and Indo-Canadians (OR 0.58; 95% CI 0.35-0.99) were less likely to have teratozospermia. No differences were seen for vitality. No differences were seen for FSH levels, however, Asians (p<0.01) and Indo-Canadians (p<0.01) were more likely to have lower testosterone.
Our study illustrates that variations in semen analyses and hormones exist in men with infertility. This may provide insight into the workup and management for infertile men from different ethnicities.
我们旨在研究种族与不育症患者精液参数及激素之间的关联。
前瞻性收集前来进行不育症评估的男性的数据，并进行回顾性分析。人口统计学和临床病史由患者自行报告。精液分析包括精液量、精子计数、活力、形态和存活率。采用2010年世界卫生组织的临界值。记录基线总睾酮和促卵泡生成素（FSH）水平。种族数据分为白种人、加拿大非洲裔、亚洲人、加拿大印度裔、加拿大原住民、西班牙裔和中东人。纳入所有数据完整的患者并进行统计分析。
共回顾了9079例患者，其中3956例患者数据完整。其中，839例（21.2%）无精子症。在调整年龄后，与白种人相比，加拿大非洲裔（优势比[OR]1.70；95%置信区间[CI]1.28 - 2.25）和亚洲人（1.34；95%CI 1.11 - 1.62）患无精子症的可能性更高。同样，加拿大非洲裔（OR 1.75；95%CI 1.33 - 2.29）患少精子症的可能性更高，而亚洲人（OR 0.82；95%CI 0.70 - 0.97）患少精子症的可能性较低。发现加拿大非洲裔（OR 1.42；95%CI 1.05 - 1.91）、亚洲人（OR 1.23；95%CI 1.01 - 1.51）和加拿大印度裔（OR 1.47；95%CI 1.01 - 2.13）精液量较低。此外，亚洲人（OR 0.73；95%CI 0.57 - 0.93）和西班牙裔（OR 0.58；95%CI 0.34 - 0.99）患弱精子症的可能性较低。亚洲人（OR 0.73；95%CI 0.57 - 0.94）和加拿大印度裔（OR 0.58；95%CI 0.35 - 0.99）患畸形精子症的可能性较低。在存活率方面未发现差异。FSH水平未发现差异，然而，亚洲人（p<0.01）和加拿大印度裔（p<0.01）的睾酮水平更有可能较低。
我们的研究表明，不育男性的精液分析和激素存在差异。这可能为不同种族不育男性的检查和管理提供见解。
