School of Chemical Sciences , Dublin City University , Glasnevin, Dublin 9 , Ireland.
Department of Chemistry , Royal College of Surgeons in Ireland , 123 St. Stephen's Green , Dublin 2 , Ireland.
J Am Chem Soc. 2019 Aug 14;141(32):12522-12526. doi: 10.1021/jacs.9b06750. Epub 2019 Jul 31.
Polypeptide nanoparticles were obtained by the miniemulsion polymerization of -(-nitrobenzyl)-l-cysteine (NBC) -carboxyanhydride (NCA). Through process optimization, reaction conditions were identified that allowed the polymerization of the water sensitive NCA to yield nanoparticles of about 220 nm size. Subsequent UV-irradiation of the nanoparticle emulsions caused the removal of the nitrobenzyl group and particle cross-linking through disulfide bond formation accompanied by the shrinkage of the particles.
采用-(-硝基苄基)-l-半胱氨酸（NBC）-羧酸酐（NCA）的细乳液聚合得到了多肽纳米粒子。通过工艺优化，确定了聚合水敏 NCA 的反应条件，得到了约 220nm 粒径的纳米粒子。随后，对纳米粒子乳液进行紫外辐照，导致硝基苄基基团的去除和通过二硫键形成的粒子交联以及粒子收缩。
